Abstract：Objective: To explore the clinical value of serum insulin growth-like factor-1 (IGF-1), vitamin A and 25-hydroxyvitamin D (25-(OH)D) levels in short stature children. Methods: 146 cases of short stature children who treated from January 2015 to May 2015 in our hospital, at the same time 109 cases height of normal healthy children as control group. Then serum levels of IGF-1, vitamin A, 25-(OH)D of all the subjects were compared, and the changes in the above indicators before and after treatment, the predictive value of ROC curve analysis indicators was obtained. Results: IGF-1, vitamin A, 25-(OH)D and height in short stature children group were lower than those in the control group (P<0.05). IGF-1, vitamin A, 25-(OH)D and height in children with short stature after treatment were higher than before treatment (P<0.05). serum IGF-1 area under the curve was 0.722, sensitive and specific degree were 0.696 and 0.706 , the area under the curve of vitamin A was 0.712, sensitive and specific degree were 0.697 and 0.691 , the area under the curve of 25-(OH) D was 0.705, sensitive and specific degree were 0.913 and 0.411, the joint detection sensitivity and specific area under the curve was 0.824, the degree of 0.783 and 0.794, under the joint detection curve area significantly higher than that of single index. Conclusion: Serum IGF-1, vitamin A and 25-(OH)D can be used as effective indicators for the screening and diagnosis of children with short stature, Appropriate intervention is recommended for children with short stature, to improve adult life
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2019, Vol. 25 
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