Abstract：Objective: To investigate the expression levels of serum CXCL16, GDF15 and Lp-PLA2 in patients with acute cerebral infarction (ACI) and its clinical significance. Methods: 100 patients with acute cerebral infarction (study group) and 100 healthy subjects (control group) were enrolled in our hospital from January 2016 to March 2018. The clinical data of patients were collected and ACI patients were performed according to TOAST. Grouping. The levels of CXCL16, GDF-15 and Lp-PLA2 in the serum of patients were detected by enzyme-linked immunosorbent assay and statistical analysis was performed. Results: Univariate analysis showed that there was a significant difference in the levels of hypertension, diabetes, hyperlipidemia, CXCL16, GDF15 and Lp-PLA2 between the ACI group and the control group (P<0.05). Serum CXCL16 levels in ACI patients were associated with BMI (P=0.001), hypertension (P=0.018), hyperlipidemia (P=0.044), and NIHSS score at admission (P=0.004); GDF15 and diabetes (P=0.042) Hyperlipidemia (P=0.005) and NIHSS score (P=0.003) at admission; Lp-PLA2 and BMI (P=0.046), hyperlipidemia (P=0.040), and NIHSS score at admission (P=0.046) related. Compared with other ACI subtypes, patients with large atherosclerosis (LAA) had the highest levels of serum CXCL16, GDF15, and Lp-PLA2 (3.64±0.63, 1338.12±513.31, 344.52±134.26, respectively), and there were statistical differences (P<0.05). Conclusion: The elevated levels of serum CXCL16, GDF-15 and Lp-PLA2 are risk factors for acute ischemic stroke.
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2019, Vol. 25 
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