Abstract：Objective: To study the effects of different analgesic regimens on postoperative analgesia and immune function in patients with cancer. Methods: 120 cases of tumor patients admitted to our hospital for surgery from January 2015 to January 2018 were included in the study and were divided into the following four groups according to simple random grouping method, including group A (sufentanil + dezocine + ondansetron, n=30), group B (suffentanil + NSAIDS + ondansetron, n=30), group C (dezocine+ NSAIDS + ondansetron, n=30) and group D (sufentanil + dezocine + NSAIDS + ondansetron, n=30). The postoperative analgesic effects and body immune function were counted among the four groups. Results: At each time point after operation, the VAS scores in resting and coughing status in group D were significantly lower than those in the other three groups (P<0.05). The frequency of intravenous analgesia (PCIA) compression in group D at each time point was less than that in the other three groups (P<0.05). There were no interactions between CD3+, CD4+, CD8+ and CD4+/CD8+ at each time point among the four groups, and there were interactions in the number of NK cells among the four groups at each time point (P<0.05), and the number of NK cells in groups B and C after operation was decreased, and there was significant difference at different time points within-groups (P<0.05), and there was no significant difference between groups B and group D at each time point (P>0.05). There was a significant difference in the adverse reactions rate among the four groups after operation (P<0.05), and there were significant differences in adverse reactions between group A and group B, between group B and group C and between group B and group D (P<0.05). Conclusions: Sufentanil + dezocine + non-steroidal anti-inflammatory drugs (NSAIDS) + ondansetron can effectively control postoperative pain in patients with cancer, reduce the immunosuppression caused by postoperative pain, and reduce the amount of anesthetic drugs, and it has high safety and is worthy of clinical promotion.
霍苗, 张倩, 张阳. 不同镇痛方案对肿瘤患者术后镇痛及免疫功能的影响[J]. 河北医学, 2019, 25(3): 563-567.
HUO Miao, ZHANG Qian, et al. Effects of Different Analgesic Regimens on Postoperative Analgesia and Immune Function in Patients with Cancer. HeBei Med, 2019, 25(3): 563-567.
2019, Vol. 25 
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