[1] Petersen B, Ramackers W, Tiede A, et al. Pigs transgenic for human thrombomodulin have elevated production of activated protein C[J].Xenotransplantation, 2009, 16(6): 486~495. [2] 赵路宁,侯力强.抗凝血因子蛋白C系统的生理及应用前景[J].血栓与止血学,2006,12(4):186. [3] Petraqlia AL, Marky AH, Walker C, et al. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact[J].Neurosurqery, 2010, 66(1): 165~172. [4] 张容, 林方昭,赖翼,等.血浆蛋白C的概述[J].检验医学与临床,2008,5(5):296~298. [5] Kerschen EJ , Fernandez JA, Cooley BC, et al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C[J].Exp Med, 2007, 204(10): 2439~2448. [6] 李洁, 辛晓敏.血浆蛋白C、蛋白S在静脉血栓患者诊断及治疗中的应用[J].中国微循环,2004,10(8):317~329. [7] Heeb MJ, Prashun D, Griffin JH, et al. Plasma protein S contains zinc essential for efficient activated protain C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor[J]. FASEB , 2009, 23 (7) : 2244~2253. [8] Dahlback B , Villoutreix BO. Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition[J].Arterioscler Thromb Vasc Biol, 2005, 25(7): 1311~1320 . [9] Yuda H, Adachi Y, Taquchi O, et al. Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice[J].Blood, 2004, 103(6): 2196~2204. [10] Brueckmann M, Hoffmann U, De Rossi L, et al. Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1cells and from human monocytes[J].Cytokine, 2004, 26 (3): 106~113. [11] Della Valle P, Pavani G, Dangelo A. The protein C pathway and sepsis[J]. Thromb Res, 2012, 129(3): 296~300. [12] Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease- activated receptor-1 and endothelial cell protein C receptor[J].Biochem, 2003, 373 (1): 65~70. [13] Schuepbach RA, Feistritzer C, Fernández JA, et al. Protection of vascular barrier integrity by activated protain C in murine models depends on protease- activated receptor-1[J].Thromb Haemost, 2009,101(4): 724~733. [14] 张锦,杨霞,张红,等.急性肺血栓栓塞症患者凝血纤溶系统功能变化相关研究[J].宁夏医科大学学报,2009,31(1):41~42. [15] Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis[J].N Engl Med, 2001, 344(10): 699~709. [16] 张本平, 梁庆成.蛋白C、蛋白S活性和缺血性脑血管病的相关性研究[J].哈尔滨大学学报,2007,41(4):365~369. [17] Thiyaqarajan M, Fernández JA, Lane SM, et al. Activated protein C promotes neovascularization and neurogenesis in postiscemic brain via protease-activated receptor [J].Neurosci, 2008, 28(48): 12788~12797.