Studies on the Correlation between islet Function Serum Interleukin-6 and Hypersensitive C-reactive Protein in Patients with Sleep Disorders with Different Glucose Tolerances
LIU Min, WANG Zhaopeng, YANG Xinhong, et al
The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China
Abstract：Objective: To observe the changes of IL-6 and hsCRP levels and pancreatic islet function in patients with different glucose tolerance , sleep disorders, to explore the correlation between sleep disorders , hyperinsulinemia, insulin resistance and inflammatory responses. Methods: 108 patients with sleep disorders who had no previous history of diabetes were selected. All patients underwent OGTT and insulin release test, tested hsCRP, IL-6 and blood lipids, assessed their sleep status in parallel with the international Pittsburgh sleep quality scale (PSQI).The results of OGTT were divided into three groups: NGT, IGR and DM. Results:The median PSQI level of NGT group, IGR group and DM group was significantly higher than that of the control group (P < 0.05). The median levels of FPG, 2h PG and HbA1c in DM group were higher than those in NGT group, IGR group and control group (all P <0.05).The median FPG level of IGR group was higher than that of control group (P<0.05).The median PG level of IGR group at 2 h was higher than that of NGT group and control group (all P <0.05).The median FINS level of DM group was higher than that of control group (P<0.05).The median levels of 2 hours insulin and HOMA-IR (homeostasis model assessment of insulin resistance) in DM group were higher than those in NGT group and control group (P<0.05).The median level of 2hIns in IGR group was higher than that in NGT group and control group (P<0.05). The median TG level of DM group was higher than that of NGT group, IGR group and control group (all P <0.05);In the process from NGT to IGR and DM, the median levels of hsCRP and IL-6 gradually increased, and the median levels of IL-6 in the NGT group, IGR group and DM group were all higher than those in the control group (P< 0.05).The median hsCRP level of IGR group and DM group was higher than that of NGT group and control group (P< 0.05). Spearman correlation analysis showed that PSQI total score was positively correlated with IL-6, hsCRP, FPG, 2h PG, HbA1c, FINS, 2 hIns, HOMA-IR and waist circumference (P<0.05). Logistic correlation analysis showed that sleep disorders were positively correlated with 2hPG [OR=1.277, 95.0% confidence interval (1.046,1.558)] and hsCRP [OR=3.203, 95.0% confidence interval (1.028,9.980)].. Conclusion: Sleep disorders are associated with hyperinsulinemia, insulin resistance, glucose metabolism disorder, and inflammatory response. Improving sleep disorders may improve pancreatic islet function and reduce inflammatory response, thus reducing the risk of impaired glucose regulation or diabetes.
刘敏, 王兆鹏, 杨新宏, 孙常铭. 不同糖耐量的睡眠障碍患者胰岛功能血清白介素-6及超敏C反应蛋白的相关性研究[J]. 河北医学, 2019, 25(5): 848-852.
LIU Min, WANG Zhaopeng, YANG Xinhong, et al. Studies on the Correlation between islet Function Serum Interleukin-6 and Hypersensitive C-reactive Protein in Patients with Sleep Disorders with Different Glucose Tolerances. HeBei Med, 2019, 25(5): 848-852.
[1] Engeda J, Mezuk B, Ratliff S, et al. Association between duration and quality of sleep and the risk of prediabetes:evidence from NHANES[J]. Diabet Med,2013, 30(6):676~680. [2] Lee J A, Sunwoo S, Kim Y S, et al. The effect of sleep quality on the development of type 2 diabetes in primary care patients[J].Korean Med Sci, 2016,31(2):240~246. [3] Chaput JP, Despres JP, Bouchard C, et al. Association of sleep duration with type 2 diabetes and impaired glucose tolerance [J].Diabetologia,2007,50(11):2298~2304. [4] Pyykkonen AJ,Isomaa B,Pesonen AK,et al. Subjective sleep complaints are associated with insulin resistance in individuals without diabetes: the PPP-Botnia Study[J]. Diabetes Care, 2012,35(11):2271~2278. [5] 任惠珠,常宝成,单春艳,杨菊红,郑妙艳,王颖,郭航,孔岩,陈莉明.2型糖尿病患者睡眠障碍与胰岛α和β细胞功能的关系[J].中华糖尿病杂志,2014,6(10):725~729. [6] Chiang Jui-Kun. Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study[J].Clin Sleep Med,2014,10(7):743~749. [7] 叶翎,孙国燕,孙玉瑶,等. 慢性低度炎症与糖尿病关系的研究进展[J]. 医学综述,2014,21:3846~3848.
2019, Vol. 25 
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