Abstract：Objective: To investigate the effects of omeprazole combined with αlipoic acid on gastrointestinal hormones and oxidative stress in patients with type 2 diabetic gastroparesis. Methods: 92 patients with type 2 diabetic gastroparesis who were admitted to the hospital during the period from February to February 2018 were enrolled in the study. They were divided into the control group and the observation group by the simple random grouping method, 46 cases in each group. The control group was treated with αlipoic acid, and the observation group was treated with omeprazole combined with α lipoic acidfor 2 weeks. Blood glucose fluctuation[daily mean amplitude of glycemic excursions (MAGE), standard deviation of blood glucose (SDBG) and the largest amplitude of glycemic excursions (LAGE)], levels of gastrointestinal hormones [gastrin (GAS), motilin (MTL), somatostatin (SS)], oxidative stress indicators [glutathione peroxidase ( GSH-Px), superoxide dismutase (SOD), reactive oxygen species (ROS)] and gastric motility indexes (stomach contraction frequency, gastric emptying time, gastric emptying rate) and adverse reactions were compared between the two groups. Results: The MAGE, SDBG, LAGE, GAS, MTL and ROS levels in the observation group were lower than those in the control group, while SS, GSH-Px and SOD were higher than the control group(P<0.05). The gastric contraction frequency and gastric emptying rate in the observation group were higher than those in the control group, and the gastric emptying time was shorter than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (4.35% vs 2.17%) (P>0.05). Conclusion: Omeprazole combined with αlipoic acid can effectively regulate gastrointestinal hormones in patients with type 2 diabetic gastroparesis, relieve oxidative stress and clinical symptoms and promote gastrointestinal function recovery.
徐丹, 张晓梅. 奥美拉唑联合α硫辛酸对2型糖尿病胃轻瘫患者胃肠激素及氧化应激反应的影响[J]. 河北医学, 2019, 25(5): 772-775.
XU Dan, et al. Effects of Omeprazole combined with Alpha Lipoic Acid on Gastrointestinal Hormones and Oxidative Stress in Type 2 Diabetic Patients with Gastroparesis. HeBei Med, 2019, 25(5): 772-775.
2019, Vol. 25 
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