Abstract：Objective: To detect the levels of serum hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with maintenance hemodialysis (MHD), and to explore the relationships between them with coronary artery calcification (CAC). Methods: 88 patients with MHD in our hospital were selected as MHD group and divided into low-risk group, middle-risk group and high-risk group according to Framingham risk score (FRS); at the same time, 56 healthy persons were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum HIF-1 and VEGF in two groups, CAC was evaluated by coronary artery calcification score (CACs), the relationships between levels of serum HIF-1, VEGF with CACs in MHD patients were analyzed. Results: Compared with the control group, the smoking rate, hemoglobin (Hb), blood glucose (GLU), C reactive protein (CRP), triglyceride (TG) and high-density lipoprotein cholesterol (HDLC) levels in MHD group were significantly different (P<0.05); the levels of serum HIF-1 and VEGF in group MHD were much higher than those in reference group (P<0.05); the levels of serum HIF-1α, VEGF and CACs score in high-risk group and middle-risk group were significantly higher than those in low-risk group (P<0.05), the levels of serum HIF-1α, VEGF and CACs in high-risk group were significantly higher than those in middle-risk group (P<0.05); the levels of serum HIF-1α and VEGF in MHD patients were positively correlated with CACs (r=0.778, 0.747, P<0.05); multivariate regression analysis showed that HDLC, FRS, HIF-1α, VEGF and CRP were the main influencing factors of CACS. Conclusion: The levels of serum HIF-1α and VEGF are high in patients with MHD, which is related to CACS, and may be involved in the occurrence and development of coronary artery calcification in MHD patients.
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2019, Vol. 25 
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