Abstract：Objective: To investigate the clinical effect on left atrial appendage occlusion with the amplatzer cardiac plug in atrial fibrillation patients with increased bleeding risk. Methods: 60 atrial fibrillation patients with increased bleeding risk by Left atrial appendage occlusion admitted in cardiology department of our hospital during March 2013 to May 2015 were selected as LAAO group and 80 atrial fibrillation patients with increased bleeding risk for the same period as the control group. The plasma ANP, left ventricular ejection fraction (LVEF) and LAA peak, 1 year and 2 year survival rates were compared of two groups before and after treatment. Results: The plasma ANP level of LAAO Group after 72 h and 3 months postoperative were significantly decreased. After 3 months, the ANP level back to 26.56±5.17 (pg/ml), there was no statistically significant difference compared with control group (P>0.05). and recovered to preoperative levels after 3 months postoperative. Compared with control group, the difference was statistically significant (P<0.05). The cardiac function index of two groups were significantly better than before treatment and the improvement of observation group was significantly better than control group, the difference was statistically significant (P<0.05). The 1 year survival rates (88.3% vs72.5 %)and 2 year survival rates(53.3% vs38.8 %) of two groups were significant difference (P< 0.05). Conclusion: LAAO with ACP seems to improve the combination of survival ,improve heart function and has good application prospect in patients with atrial fibrillation and increased bleeding risk.
关欣,白志生. Amplatzer封堵器在左心耳封堵术治疗出血风险性心房颤动患者中的临床疗效[J]. 河北医学, 2017, 23(12): 2005-2009.
GUAN Xin, BAI Zhisheng. Clinical Effect on Left Atrial Appendage Occlusion with the Amplatzer Cardiac Plug in Atrial Fibrillation Patients with Increased Bleeding Risk. HeBei Med, 2017, 23(12): 2005-2009.
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2017, Vol. 23 
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