低等效剂量甲泼尼龙和高等效剂量地塞米松在全频下降型突发性聋的治疗效果

doi:10.3969/j.issn.1006-6233.2017.12.015

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摘要 目的:研究并比较低等效剂量甲泼尼龙与高等效剂量地塞米松对全频下降型突发性聋的治疗效果。方法:于2014年1月至2016年12月期间,选取100例全频下降型突发性聋患者作为研究对象,采取计算机随机分为两组,每组50例,A组采取甲泼尼龙治疗,B组采取地塞米松治疗,治疗2周后,比较两组患者的临床疗效、全频纯音听阈均值、不良反应发生率。结果:A组、B组的总有效率分别为88%、84%,差异无统计学意义(P>0.05);治疗后,两组患者的全频纯音听阈均值提高,差异具有统计学意义(P<0.05),而治疗后两组患者的全频纯音听阈均值比较,差异无统计学意义(P>0.05);A组、B组的不良反应发生率分别为6%、4%,差异无统计学意义(P>0.05)。结论:低等效剂量甲泼尼龙、高等效剂量地塞米松治疗全频下降型突发性聋均具有显著疗效,可有效改善患者的听力,且二者安全性均十分可靠。

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	王青海
	熊向菁
	李俊娟

关键词 ：全频下降型, 突发性聋, 甲泼尼龙, 地塞米松

Abstract：Objective: To study and compare the treatment effect of low equivalent dose of methylprednisolone and high dose equivalent of dexamethasone for full frequency descent type of sudden deafness. Methods: From January 2014 to December 2016, 100 cases of patients with full frequency decline of sudden sensorineural hearing loss were selected as the research object, and they were randomly divided into two groups by taking computer random number method, each group had 50 cases, A group was treated with methylprednisolone, B group was treated with dexamethasone, after 2 weeks of treatment, the clinical curative effect, full frequency pure tone average and the incidence of adverse reaction were compared between two groups. Results: The total effective rate in A group and B group were 88%, 84%, the difference was not statistically significant (P>0.05); after treatment, the full frequency pure tone average in two groups were significantly improved (P<0.05), and the full frequency pure tone average in two groups was compared, there was no statistically significant difference (P>0.05); the adverse reactions in A group and B group were respectively 6%, 4%, the difference was not statistically significant (P>0.05). Conclusion: The low dose methylprednisolone and high effective dose of dexamethasone in the treatment for full frequency descent type of sudden deafness both have significant curative effect, can effectively improve the hearing of the patients, and the safety of the two medicine are very reliable.

Key words： Full frequency descent type Sudden deafness Methylprednisolone Dexamethasone

基金资助:青海省科学技术成果公报,[编号:(2016年)9632016Y0236]

引用本文:

王青海,熊向菁,李俊娟. 低等效剂量甲泼尼龙和高等效剂量地塞米松在全频下降型突发性聋的治疗效果[J]. 河北医学, 2017, 23(12): 1988-1990.
WANG Qinghai, XIONG Xiangjing, LI Junjuan. Effect of Low Dose Methylprednisolone and High Effective Dose of Dexamethasone Decreased with Sudden Sensorineural Hearing Loss in the whole Frequency Therapeutic Effect. HeBei Med, 2017, 23(12): 1988-1990.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.12.015 或 http://www.hbyxzzs.cn/CN/Y2017/V23/I12/1988