Abstract：Objective: To explore the prognostic value of HPV16-E6-DNA in cervical cancer. Methods: A retrospective analysis of our hospital in January 2014 ~2017 year in March 72 cases of cervical cancer patients with clinical data, blood tests, using fluorescence quantitative (PCR) technique for detection of HPV16-E6-DNA virus load, according to the test results of the patients were divided into two groups, namely low load and high load group, using fluorescence quantitative (RT-PCR) determination of cervix cancer tissue HPV16-E6-DNA viral load, using Kaplan-Meier to calculate the survival rates of the two groups, using the factor Cox regression analysis in patients with 5-year-survival rates. Results: The expression levels of HPV16-E6-DNA viral load in patients with cervical cancer were related to age, FIGO stage and lymph node metastasis (P<0.05); The 1, 3 and 5 year survival rates of the patients in the low load group were 95.66%, 89.31% and 74.30% respectively; The 1, 3 and 5 year survival rates of the patients in the high load group were 89.10%, 62.61% and 51.36% respectively; The survival rate of patients in the low load group was significantly higher than that of high load group, the difference was statistically significant (P<0.05); Cox regression analysis showed that HPV16-E6-DNA viral load and lymph node metastasis were the important factors affecting the prognosis of patients with cervical cancer (P<0.05). Conclusion: HPV16-E6-DNA virus is an important predictor of the prognosis of cervical cancer patients. It is an important factor in the prognosis of cervical cancer after radical resection. It is also an independent factor in the survival rate of cervical cancer after radical operation.
2017, Vol. 23 
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