Abstract：Objective: To investigate the effect of Qingrejiedu prescription on the level of IFN-, IL-4 and IL-6 of children with refractory mycoplasma. Methods: 90 patients with RMPP were enrolled in this study during January 2015 to June 2016. All the patients were divided into control group and observation group, 45cases in each group according to the number of random table method. 45 healthy children who were admitted to our hospital for the same period were selected as health group. The children in control group were treated with azithromycin. The children in the observation group were treated with Qingrejiedu on the basis of the control group. The levels of CD4+, CD8+, CD4+ / CD8+, IL-6, IFN-γ, IL-4 in serum and IL-6, IFN-γ and IL-4 in BALF were measured before and after treatment. Results: The levels of CD4+, CD4+ / CD8+ in the control group and the observation group were significantly lower than those in the healthy group (P<0.05), and the levels of CD8 + were significantly higher than those in the healthy group (P<0.05) before treatment. After treatment, the levels of CD4+, CD8+, CD4+/CD8+ in the two groups were significantly improved (P<0.05), and the observation group was significantly better than that of control group (P<0.05). The levels of IFN-γ, IL-4 and IL-6 in the serum and BALF of the control group and the observation group were significantly higher than those in the healthy group before treatment (P<0.05) before treatment. After treatment, the serum and BALF of the two groups were significantly improved (P<0.05), and the observation group was significantly lower than those of control group (P<0.05). Conclusion: Qingrejiedu can effectively improve the level of cytokines and inflammatory factors in children with RMPP, improving immunity system of children.
朱海艳. 清热解毒方对小儿难治性支原体肺炎患者IFN-γ IL-4 IL-6水平的影响[J]. 河北医学, 2017, 23(7): 1132-1134.
ZHU Haiyan. Effect of Qingrejiedu prescription on the Level of IFN-γ IL-4 and IL-6 of Children with Refractory Mycoplasma Pneumonia. HeBei Med, 2017, 23(7): 1132-1134.
[1] Waites K B, Balish M F, Atkinson T P. New insights into the pathogenesis and detection of mycoplasma pneumoniae infections[J].Future Microbiology, 2017, 3(6): 635~648. [2] Zhengxiu Luo MD PhD, Jian L M, Enmei Liu MD PhD, et al. Effects of prednisolone on refractory mycoplasma pneumoniae pneumonia in children[J].Pediatric Pulmonology, 2014, 49(4): 377~380. [3] Inamura N, Miyashita N, Hasegawa S, et al. Management of refractory Mycoplasma pneumoniae pneumonia: utility of measuring serum lactate dehydrogenase level[J].Journal of Infection & Chemotherapy, 2014, 20(4): 270~273. [4] 王勤, 朱珊,赵义红,等.清肺活血方联合阿奇霉素治疗难治性小儿支原体肺炎的平行对照研究[J].中国中西医结合杂志,2015,35(5):545~548. [5] Wang M, Wang Y, Yan Y, et al. Clinical and laboratory profiles of refractory mycoplasma pneumoniae pneumonia in children[J].International Journal of Infectious Diseases Ijid Official Publication of the International Society for Infectious Diseases, 2014, 29C(C): 18~23. [6] You S Y, Jeong J H, Yang E A, et al. Effects of methylprednisolone pulse therapy on refractory mycoplasma pneumoniae pneumonia in children[J].Allergy Asthma & Immunology Research, 2014, 6(1): 22~26. [7] Shu L H, Shang Y X, Cai X X, et al. Alterations of SP-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluid in children with mycoplasma pneumoniae pneumonia[J].Zhonghua Er Ke Za Zhi, 2013, 51(10): 779~782. [8] 李柏,廖素雯,赵健,等.肺炎支原体肺炎的诊治[J].中国实用儿科杂志,2008,34(8):3643~3643. [9] 中华人民共和国中医药行业标准.中医病症诊断疗效标准[M].北京:国家中医药管理局,1995.126. [10] Dong X P, Dong Y Q, Ma L, et al. Surveillance of drug-resistance in mycoplasma pneumoniae and analysis of clinical features of Mycoplasma pneumoniae pneumonia in childhood[J].2013, 126(22): 4339. [11] Wu P S, Chang L Y, Lin H C, et al. Epidemiology and clinical manifestations of children with macrolide-resistant mycoplasma pneumoniae pneumonia in Taiwan[J].Pediatric Pulmonology, 2013, 48(9): 904~911. [12] Chu W, Hui X U, Gao S, et al. Clinical significance of high sensitive C-reactive protein and immune function in children with mycoplasma pneumoniae pneumonia[J].Journal of Clinical Pediatrics, 2014, 32(5): 456~458. [13] 童晓萍,蔡彦,王维亮,等.成人肺炎支原体肺炎中医证候分析及与炎症指标的关系[J].广东医学,2014,35(2):291~292. [14] 车颖悟,佟晓辉,黄晓娟.自拟中药方联合阿奇霉素治疗小儿支原体肺炎的疗效观察[J].中国药房,2013,15(20):1875~1876
2017, Vol. 23 
冀公网安备13080202000677号