Abstract：Objective: To compare the prevalence of thyroid nodules among people with different glucose tolerance, and to investigate the relationship between insulin resistance and the incidence of thyroid nodules. Methods: three groups of subjects were collected in this study, 342 patients with type 2 diabetes (T2DM), 145 normal glucose tolerance (NGT), and 180 patients with impaired glucose regulation (IGR), to compare between the three groups of thyroid nodule detection rate, HOMA - IR and Matsuda index. Divided into the nodules group and non-nodules group,and compared the differences between the two groups of gender, age, BMI, HOMA - IR and Matsuda index and correlation. Results: Thyroid nodules prevalence in T2DM group was significantly higher than in IGR and NGT group (P < 0.05);At the same time, the BMI, HOMA IR and TSH levels in T2DM group were higher than the other two groups (P < 0.05); The Matsuda index of T2DM group was lower. The BMI, FPG, HOMA-IR in Thyroid nodule group were higher than those in non- nodules group, P < 0.05; While the Matsuda index is lower than the non-nodule group, P < 0.05. Logistic regression analysis was carried out on the thyroid nodules, and the results showed that thyroid nodule and age, BMI, fasting glucose, HOMA-IR were positively correlated (OR =1.061,1.121,1.114,1.225,95％CI =1.015～1.079,1.057～1.324,1.142～ 1.416,1.112～ 1.428), and negatively correlated with Matsuda index (OR=0.385,95％CI =0.298～0.479). Conclusion: The prevalence of thyroid nodules significantly is higher in the diabetic population, age, gender, fasting glucose, BMI and insulin resistance are independent risk factors for the development of thyroid nodules disease.
[1] 王朝迅.2型糖尿病与甲状腺结节相关性的研究[J].中国医学创新,2012,36:7~9. [2] 张春玉,曾洪利,刘颖,等.甲状腺结节与代谢综合征及其组分的相关性分析[J].中华内分泌代谢杂志,2012,28(2):132~135. [3] Semra A,Alptekin G,Altug K,et al.Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area[J].Eur Endocrinol,2009,161:599~605. [4] Bi Y,Zeng L,Zhu D,et al.Association of beta-cell function and insulin sensitivity with fasting and 2h plasma glucose in a large Chinese population[J].Diabetes Obes Metab,2012,14(2):174~180. [5] Ogilvie JB,Piatigovsk EJ,Clark OH. Current status of fine needle aspiration for thyroid nodules[J].Adv Surg,2006,40:223~238. [6] Gharib H,Papiui E,Pasehke R,et al.American association of clinical endocfinologists,associazione medici endocrinologi,and European thyroid association medical guidelines for chuieal practice for the diagnosis and management of thyroid nodules [J].Endocr Pract,2010,16 ( Suppl 1):1~43. [7] Saad AG,Kumar S,Ron E,et al.Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure[J].Clin Endocrinol Metab, 2006,91(7): 2672~2677. [8] Reaven GM.Role of insulin resistance in human disease[J].Diabetes,1988,37:1595~1607. [9] Ayturk S,Gursoy A,Kut A,et al. Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area[J].Eur Endocrinol,2009,161(4):599~605. [10] Lambadiari V,Mitrou P,Maratou E,et al.Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes[J].Endocrine,2011,39:28~31. [11] Anil C,Akkurt A,Ayturk S,et al.Impaired glucose metabolism is a risk factor for increased thyroid volume and nodule prevalence in a mild to moderate iodine deficient area[J].Metabolism,2013,62(7):970~975.
2017, Vol. 23 
冀公网安备13080202000677号