Abstract：Objective: To observe the effect of Gegen Qinlian Decoction in treating type 2 diabetes patients with dampness-heat syndrome and the effect of intestinal flora. Methods: Forty-two type 2 diabetes patients with damp-heat syndrome were randomly divided into 2 groups:the control group was treated with Western medicine alone, and the experimental group was treated with integrated Traditional and Western medicine.The fecal samples were collected to extract bacterial genome DNA, and the composition was investigated by Illumina Miseq high-throughput sequencing of the V3 region of the 16S rRNA gene. Species in feces were also measured by real-time quantitative PCR. The relationship between effectiveness and gut microbiota was observed after treatment. Results: The total effectiveness of experimental group was higher than that of control group. Bacteroides correlated negatively with the reduction rate of dampness-heat syndrome, while Fusobacterium correlated positively with the reduction rate of dampness-heat syndrome. Conclusion: The combination of Gegen Qinlian Decoction with Western medicine has the effective treatment among type 2 diabetes patients with dampness-heat syndrome, and Bacteroides and Fusobacterium could be the markers of effectiveness.
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2016, Vol. 22 
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