Abstract：Objective: To analyze the application value of midazolam CLTCI with BIS feedback control in ICU sedation. Methods: 120 patients admitted in ICU of Suizhou Affiliated Hospital to Hubei Medicine University from January 2015 to December 2016 selected as the research objects, were randomly divided into group A of 40 cases using micro pump continuous infusion, group B of 40 patients with target controlled infusion, (target controlled, infusion, TCI) group C of 40 cases using the closed-loop target controlled infusion (CLTCI) and APACHE were performed within 24h after admission II score. The data of HR, RR, MAP before sedation, BIS and sedation effect were recorded and compared. Results: Compared with the basic values of MAP and HR, the MAP of three groups decreased obviously after sedation, but there was no statistical significance (P > 0.05); The BIS values corresponding to the different Ramsay scores were negatively correlated in the three groups (correlation coefficient, r=-0.856). With the depth of sedation, BIS values of patients in three groups were significantly decreased. Among them, the BIS value corresponding to 3 points, 4 points, 5 points and 6 branches was significantly lower than the corresponding BIS value of the 1 branche. The corresponding BIS values of 4 points and 6 branches were significantly lower than the corresponding BIS values of the 2 branches, all of which were statistically significant (P < 0.05). The corresponding values of the 5 branches were statistically significant (P < 0); There was significant difference between the three groups in maintaining ideal sedation time, 60~80 range, BIS value, time percentage and average dosage of midazolam in 24h, and statistically significant (P < 0.05); Group C maintain ideal sedation time and the percentage reached 60 ~ 80 BIS value of the percentage of time was significantly higher than that of group A, group B, group C 24h, the average amount of midazolam significantly less than group A and group B were statistically significant (P < 0.05). Conclusions: Compared with the continuous infusion and TCI infusion, the CLTCI can effectively reduce the dosage of midazolam while maintaining sedation, and it is worthy of clinical application.
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2017, Vol. 23 
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