[1] Willner P, Towell A, Sampson D, et al. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant[J].Psychopharmacology,1987,93(3): 358~364. [2] Hochstrasser C,Ullrich B,Sperner-unterweger, et al. Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe necleus organotypic brain slices[J].Neuroscience,2011,184:128~138. [3] Willner P. The validity of animal models of depression[J].Psychopharmacology,1984,83(1): 1~16. [4] Willner P. Animal models of depression: an overview[J].Pharmacol Ther,1990,45(3): 425~455. [5] Katz RJ. Animal model of depression: pharmacological sensitivity of a hedonic deficit[J].Pharmacol Biochem Behav,1982,16(6): 965~968.