Abstract：Objective: To integrative clinical effect of analgesia and sedation on cerebral metabolism in patients with severe subarachnoid hemorrhage. methods: 55 patients with severe subarachnoid hemorrhage were chosen for this investigation. Fentanyl citrate injection, midazolam injection and propofol injection were used for the treatment of severe subarachnoid hemorrhage. The carotid, jugular and central venous oxygen saturation before, during and after analgesia and sedation treatment were detected. Results: Before sedation and analgesia treatment, the carotid, jugular and central venous blood oxygen saturation were (0.86±0.19), (0.46±0.07) and (0.48±0.05). 2h after analgesia and sedation treatment started, carotid artery oxygen saturation decreased significantly (t=4.63, P < 0.05); while the jugular vein (t=7.62, P < 0.05) and central vein (t=7.53, P < 0.05) oxygen saturation increased significantly. After analgesia and sedation treatment, carotid artery oxygen saturation decreased, while jugular vein and central venous oxygen saturation increased, and the results had no significant difference with the results before treatment (P > 0.05). Conclusion: The use of analgesia and sedation treatment of patients with severe subarachnoid hemorrhage can not only reduce the body metabolism, but also reduce the cerebral metabolism. Whether analgesia and sedation treatment can improve the prognosis of severe subarachnoid hemorrhage needs further study.
李深誉, 阳永东. 镇痛镇静对重症蛛网膜下腔出血患者脑代谢的影响[J]. 河北医学, 2017, 23(1): 111-113.
LI Shenyu, YANG Yongdong, YAN Jun, et al. Effect of Analgesia and Sedation on Cerebral Metabolism in Patients with Severe Subarachnoid Hemorrhage. HeBei Med, 2017, 23(1): 111-113.
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2017, Vol. 23 
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