Abstract：Objective: To explore the mechanism of perindopril in lipid metabolism disorders in obese rats and its effect on the AMPK/Sirt1 pathway. Methods: Forty male SD rats were randomly divided into four groups: blank group, model group, perindopril + inhibitor group, and perindopril group, with 10 rats in each group. Rats in the model, perindopril + inhibitor, and perindopril groups were fed a high-fat diet to establish an obesity model, while the blank group received no treatment. After successful modeling, the blank and model groups were treated with the same amount of saline, the perindopril + inhibitor group received 2 mg/kg perindopril + 5 mg/kg Dorsomorphin, and the perindopril group received 2 mg/kg perindopril. The average area of epididymal adipocyte cells, blood lipid and blood glucose levels, liver index, liver mass, body mass, Lee's index, body weight, and protein expression of AMPK and Sirt1 were compared among groups. Results: Compared with the blank group, the model and perindopril + inhibitor groups showed increased average area of epididymal adipocytes, LDL-C, TG, TC, FPG, 0.5hPG, 1hPG, 2hPG, liver mass, body mass, Lee's index, final body weight, and weight gain, while HDL-C levels, liver index, and protein expression of AMPK and Sirt1 were decreased (P<0.05). Compared with the model group, the perindopril group showed decreased average area of epididymal adipocytes, LDL-C, TG, TC, FPG, 0.5hPG, 1hPG, 2hPG, liver mass, body mass, Lee's index, final body weight, and weight gain, while HDL-C levels, liver index, and protein expression of AMPK and Sirt1 increased (P<0.05). Compared with the perindopril group, the perindopril + inhibitor group showed increased average area of epididymal adipocytes, LDL-C, TG, TC, FPG, 0.5hPG, 1hPG, 2hPG, liver mass, body mass, Lee's index, final body weight, and weight gain, while HDL-C levels, liver index, and protein expression of AMPK and Sirt1 were decreased, with significant differences (P<0.05). Conclusion: Perindopril can effectively reduce body weight, decrease the average area of epididymal adipocytes, and improve glucose and lipid metabolism in rats. Its mechanism may be related to the AMPK/Sirt1 pathway.
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2025, Vol. 31 
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