Association between Serum CTRP3 BGLAP sCD44 Levels with Fracture Healing in Patients with Traumatic Intertrochanteric Femoral Fractures Underwent Proximal Femoral Nail Anti-rotation
HE Jinhai, ZOU Guoyou, JI Bingqing, et al
Yancheng No.1 People's Hospital, Yancheng First Hospital Affiliated of Nanjing University Medical College, Jiangsu Yancheng 224000, China
Abstract：Objective: To observe the serum levels of complement C1q/tumor necrosis factor-related protein 3 (CTRP3), osteocalcin (Bglap) and soluble phagocytic glycoprotein-1 (sCD44) in patients with traumatic intertrochanteric femoral fractures (IFF) underwent proximal femoral nail anti-rotation (PFNA), and to analyze their correlation with fracture healing effect. Methods: A total of 112 patients with traumatic IFF in the hospital from January 2019 to December 2023 were included in the study. The serum levels of CTRP3, BGLAP and sCD44 after PFNA were measured among all patients, and the association between these indicators and fracture healing effect was analyzed. Results: After PFNA treatment, twenty-three cases representing 112 patients had poor healing. The levels of serum CTRP3 and BGLAP in the poor healing group were significantly lower than those in the good healing group, while the sCD44 level was significantly higher (P<0.05). Univariate analysis found that age, smoking and surgical time were related to poor postoperative healing (P<0.05). Logistic regression analysis showed that age, surgical time and sCD44 level were risk factors affecting poor postoperative healing, and all the associations were statistically significant (P<0.05). Serum CTRP3 and BGLAP levels were protective factors for poor healing (P<0.05). Receiver operating characteristic (ROC) curves revealed that the area under the ROC curve (AUC) of CTRP3, BGLAP and sCD44 in evaluating poor healing after PFNA was 0.703, 0.743 and 0.724, respectively, but the AUC of CTRP3+BGLAP+sCD44 in evaluating poor postoperative healing was 0.803, with the sensitivity and specificity under the maximum Youden index of 0.957 and 0.528 respectively. Conclusion: The decreases of serum CTRP3, BGLAP and sCD44 levels have a certain association with poor fracture postoperative healing in patients with traumatic IFF underwent PFNA, and have a high evaluated value on fracture healing effect.
何金海, 邹国友, 纪秉青, 丁亚军, 刘红兵. 血清CTRP3 BGLAP及sCD44水平与创伤性股骨粗隆间骨折患者PFNA术后骨折愈合的关联性研究[J]. 河北医学, 2024, 30(12): 2091-2096.
HE Jinhai, ZOU Guoyou, JI Bingqing, et al. Association between Serum CTRP3 BGLAP sCD44 Levels with Fracture Healing in Patients with Traumatic Intertrochanteric Femoral Fractures Underwent Proximal Femoral Nail Anti-rotation. HeBei Med, 2024, 30(12): 2091-2096.
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2024, Vol. 30 
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