Abstract：Objective: To investigate the correlation between lung infection and tumor necrosis factor-alpha (TNF-α) gene polymorphism after heart valve replacement (HVR) surgery. Methods: A total of 80 patients with HVR in Nanjing Drum Tower Hospital from January 2020 to December 2023 were retrospectively selected, and they were divided into lung infection group (30 cases) and non-lung infection group (50 cases) according to the presence or absence of postoperative lung infection. Results: A total of 43 strains of pathogenic bacteria were detected in 30 patients with pulmonary infection, mainly gram-negative bacteria (62.79%), with Escherichia coli (20.93%). Followed by Gram-positive bacteria (25.58%), with Staphylococcus aureus (13.95%). Finally, fungi accounted for 11.63%, with Candida alba (9.30%). The lung infection group had significantly higher the proportion of age, hyperlipidemia, diabetes and cerebral infarction, significantly more the amount of intraoperative blood loss, and significantly longer the duration of ventilator use, cardiopulmonary bypass and ICU stay compared to the non-lung infection group (all P<0.05). The lung infection group presented significantly lower the proportion of the left ventricular ejection fraction, GG genotype frequency of TNF-α gene rs1800629, and G allele frequency and significantly higher the proportion of GA, AA and A relative to the non-lung infection group (all P<0.05). The influencing factors of postoperative pulmonary infection included ICU stay time, extracorporeal circulation time, TNF-α gene rs1800629 site AA (P<0.05). Conclusion: There is a significant correlation between lung infection after HVR and TNF-α gene polymorphism, and the latter is a predisposing factor for the former.
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2024, Vol. 30 
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