Abstract：Objective: To analyze the value of serum creatine kinase isoenzyme (CK-MB) combined with blood lactic acid on the prediction of short-term prognosis in patients with multiple trauma.Methods: Totally 119 patients with multiple trauma in the hospital were collected from January 2020 to December 2023 as the study subjects, and were divided into survival group (n=99) and death group (n=20) by means of 28-day prognosis status. Serum CK-MB and blood lactic acid levels of all subjects were measured after admission. The prediction model with CK-MB and blood lactic acid as variables was constructed by binary Logistic regression analysis. Receiver operating characteristic curve (ROC) was performed to analyze the predictive value of serum CK-MB and blood lactic acid on short-term prognosis of patients.Results: The levels of serum CK-MB and blood lactic acid in the death group were higher than those in the survival group (P<0.05). Logistic regression analysis indicated that CK-MB and blood lactic acid were independent predictors of short-term prognosis in patients with multiple trauma, and the prediction model was logit(P)=-6.789 + 0.188 × CK-MB + 0.234 × blood lactic acid. ROC curve analysis showed that the area under the curve (AUC), sensitivity and specificity of serum CK-MB combined with blood lactic acid in predicting the short-term prognosis were 0.997, 100.00% and 98.99%, which were better than each indicator alone (P<0.05).Conclusion: Serum CK-MB and blood lactic acid are closely related to the short-term prognosis in patients with multiple trauma. Early detection of CK-MB and blood lactic acid levels has certain predictive value on the short-term prognosis of patients with multiple trauma, and the combined prediction of the two indicators is more effective.
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2024, Vol. 30 
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