Abstract：Objective: To investigate the effects of Haurologic breast nodule vacuum rotary excision on neurotransmitters 5-hydroxytryptamine (5-HT), malondialdehyde (MDA) and tumor necrosis factor- α (TNF-α) in patients with breast nodules. Methods: A retrospective analysis was performed on 148 patients with breast nodules admitted to our hospital from April 2020 to May 2023. 46 cases were excluded by inclusion and exclusion criteria, and 102 cases were finally included. According to different surgical methods, they were divided into control group ( n=50, traditional small incision treatment ) and experimental group ( n=52, Holloway vacuum rotary resection of breast nodules ). The surgical observation indexes, the changes of 5-HT, MDA and TNF-α levels before and after treatment, the good rate of postoperative recovery, the incidence of complications, and the recurrence rate of nodules were compared between the two groups. Results: The total operation time of the experimental group was shorter than that of the control group, the incision length was shorter, the amount of blood loss and the total postoperative hospitalization days were less than that of the control group (P<0.05). The levels of 5-HT, MDA and TNF-α increased from before treatment to 3 days after treatment, and the levels of 5-HT, MDA, and TNF-α decreased from 3 days after treatment to 7 days after treatment (P<0.05). The levels of 5-HT, MDA and TNF-α in the experimental group were lower than those in the control group at 1 day, 3 days, and 7 days after treatment (P<0.05). The good recovery rates of control group and experimental group were 78.00% and 92.31%, respectively, and the rate of good recovery was higher in the experimental group (P<0.05). When comparing the recurrence rate of nodules in the two groups, the difference was not statistically significant (P>0.05), and the total complication rate of the experimental group (5.76%) was lower than that of the control group (20.00%) (P<0.05). Conclusion: Halotiere vacuum rotation of breast nodules has relatively little effect on the levels of 5-HT, MDA and TNF-α in patients with breast nodules, and the incidence of complications is low, which has a positive role in promoting the early postoperative recovery of patients.
王静, 周煜栋, 郭萍利. 豪洛捷乳腺结节真空旋切术对乳腺结节患者5-HT MDA及TNF-α的影响[J]. 河北医学, 2024, 30(10): 1639-1643.
WANG Jing, ZHOU Yudong, GUO Pingli. Effect of vacuum Rotary Excision of Breast Nodules in Patients with Breast Nodules with 5-HT MDA and TNF-α by Haurologie. HeBei Med, 2024, 30(10): 1639-1643.
2024, Vol. 30 
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