Abstract：Objective: To investigate the relationship between serum cyclooxygenase-2 (COX-2), pituitary tumor transforming gene 1 (PTTG1), toll-like receptor 4 (TLR4) levels and clinicopathological features, prognosis, and survival of primary laryngeal cancer.Methods: A total of 105 patients with primary laryngeal cancer and 105 patients with benign laryngeal lesions in Dazhou City Central Hospital of Sichuan Province from May 2021 to March 2023 were selected as observation and control groups, respectively. The serum COX-2, PTTG1 and TLR4 levels of the two groups were compared, and the relationship between serum COX-2, PTTG1 and TLR4 levels, and clinicopathological features was analyzed using multiple linear regression, and the prognostic survival rate of the patients with different serum COX-2, PTTG1, and TLR4 levels was compared in the follow-up of 3 years.Results: The levels of COX-2, PTTG1, and TLR4 in the observation group were (38.89±12.14) ng/L, (140.17±30.25) pg/mL, and (13.94±3.25) ng/mL, respectively, which were higher than those in the control group (17.63±5.09) ng/L, (98.49±15.63) pg/mL, and (8.72±2.13) ng/mL (t=16.549, 12.543, 13.765, all P<0.05). Multiple linear regression analysis showed that clinical stage (partial regression coefficient:0.714, 0.722, 0.719), tumor differentiation degree (partial regression coefficient:0.756, 0.749, 0.798), and lymph node metastasis (partial regression coefficient:0.802, 0.798, 0.713) were the influencing factors for the levels of serum COX-2, PTTG1, and TLR4 in patients with primary laryngeal cancer (P<0.05). The 3-year overall survival rate and overall survival rate of the COX-2 high-level subgroup were 80.77% and 71.15%, respectively, which were significantly higher than those of the low-level subgroup 95.83% and 87.50% (P<0.05); the 3-year overall survival rate and overall survival rate of the PTTG1 high-level subgroup were 80.39% and 68.63%, respectively, which were significantly higher than those of the low-level subgroup 95.92% and 89.80% ( P<0.05); 3-year overall survival rate and overall survival rate of TLR4 high-level subgroup were 78.85% and 71.15%, respectively, which were significantly higher than those of 97.92% and 87.50% in the low-level subgroup (P<0.05).Conclusion: The levels of serum COX-2, PTTG1, and TLR4 are high in patients with primary laryngeal cancer, and their high levels are related to clinical stage, tumor differentiation, and lymph node metastasis. Detection of COX-2, PTTG1, and TLR4 levels can reflect the prognosis and survival of patients to a certain extent.
2024, Vol. 30 
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