血小板参数 NF-κB IL-6水平检测与肝硬化患者合并上消化道出血病情及转归的关联性研究

doi:10.3969/j.issn.1006-6233.2024.08.029

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1230 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 分析血小板参数、血清核因子-κB(NF-κB)、白介素-6(IL-6)水平与肝硬化患者合并上消化道出血病情及转归的关联性。方法: 将2021年1月至2024年1月于本院就诊的155例肝硬化合并上消化道出血患者为研究对象,依据入院治疗前的失血量将其分为轻度组(n=70)和中重度组(n=85)。另外依据其病情转归情况分为预后良好组(n=122)与预后不良组(n=33),测定所有研究对象的血小板参数[血小板计数(PLT)、血小板平均体积(MPV)、血小板比容(PCT)、血小板分布宽度(PDW)]、血清NF-κB、IL-6水平,以Spearman秩相关性分析血小板参数、NF-κB、IL-6水平与肝硬化合并上消化道出血患者病情及转归的关联性。结果: 中重度组的PLT、MPV、PCT、PDW、血清NF-κB、IL-6水平高于轻度组(P<0.05);预后不良组的PLT、MPV、PCT、PDW、血清NF-κB、IL-6水平高于预后良好组(P<0.05)。Spearman秩相关性分析显示,PLT、MPV、PCT、PDW、血清NF-κB、IL-6水平与肝硬化合并上消化道出血患者的病情严重程度均呈正相关(r=0.226,0.311,0.387,0.311,0.351,0.386,P<0.05)。结论: 血小板参数、NF-κB、IL-6水平与肝硬化合并上消化道出血患者的病情及转归密切相关,早期检测血清上述指标可为临床评估病情及转归提供一定的参考依据。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	蔡旭
	许帅
	尚帅

关键词 ：肝硬化, 上消化道出血, 血小板参数, 核因子-κB, 白介素-6, 关联性, 病情, 转归

Abstract：Objective: To analyze the correlation between platelet parameters, serum nuclear factor-κB (NF-κB), interleukin-6 (IL-6) levels, and the disease severity and prognosis in patients with cirrhosis complicated by upper gastrointestinal bleeding (UGIB).Methods: A total of 155 patients with cirrhosis complicated by UGIB, treated at our hospital from January 2021 to January 2024, were included in the study. Based on the amount of blood loss before admission, they were divided into a mild group (n=70) and a moderate to severe group (n=85). Additionally, based on the prognosis, they were categorized into a good prognosis group (n=122) and a poor prognosis group (n=33). Platelet parameters [platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW)], serum NF-κB, and IL-6 levels were measured in all patients. Spearman rank correlation analysis was used to evaluate the relationship between these parameters and the severity and prognosis of cirrhosis complicated by UGIB.Results: The PLT, MPV, PCT, PDW, serum NF-κB, and IL-6 levels in the moderate to severe group were significantly higher than those in the mild group (P<0.05). Similarly, these parameters were higher in the poor prognosis group compared to the good prognosis group (P<0.05). Spearman rank correlation analysis indicated a positive correlation between PLT, MPV, PCT, PDW, serum NF-κB, IL-6 levels, and the severity of cirrhosis complicated by UGIB (r=0.226,0.311,0.387,0.311,0.351,0.386; P<0.05).Conclusion: Platelet parameters, NF-κB, and IL-6 levels are closely related to the severity and prognosis of patients with cirrhosis complicated by UGIB. Early detection of these serum indicators can provide a reference for clinical assessment of disease severity and prognosis.

Key words： Cirrhosis Upper gastrointestinal bleeding Platelet parameters Nuclear factor-κB Interleukin-6 Correlation Disease severity Prognosis

基金资助:2019年安徽省重点研究与开发计划项目,(编号:201904a07020108)

引用本文:

蔡旭, 许帅, 尚帅. 血小板参数 NF-κB IL-6水平检测与肝硬化患者合并上消化道出血病情及转归的关联性研究[J]. 河北医学, 2024, 30(8): 1386-1390.
CAI Xu, XU Shuai, SHANG Shuai. Correlation Study of Platelet Parameters NF-κB IL-6 Levels with Disease Severity and Prognosis in Patients with Cirrhosis Complicated by Upper Gastrointestinal Bleeding. HeBei Med, 2024, 30(8): 1386-1390.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.08.029 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I8/1386

[1] Targownik LE,Fisher DA,Saini SD.AGA clinical practice update on de-prescribing of proton pump inhibitors:expert review[J].Gastroenterology,2022,162(4):1334-1342.
[2] Kruger AJ,Abougergi MS,Jalil S,et al.Outcomes of nonvariceal upper gastrointestinal bleeding in patients with cirrhosis:a national analysis[J].Clin Gastroenterol,2023,57(8):848-853.
[3] Tatliparmak AC,Dikme O,Dikme O,et al.Cancer,platelet distribution width,and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding[J].Peer,2022(10):14061.
[4] 唐闯,张鑫,张婷.艾司奥美拉唑镁联合白眉蛇毒血凝酶对非静脉曲张性上消化道出血的治疗效果观察[J].上海交通大学学报(医学版),2022,42(11):1576-1581.
[5] 陈峥,彭亚文,孙虹雨.核因子-κB信号通路相关因子在急性上消化道出血患者中的表达及相互关系[J].中国医刊,2023,58(7):714-718.
[6] 中华医学会肝病学分会.肝硬化诊治指南[J].中华肝脏病杂志,2019,27(11):846-865.
[7] 中国医师协会急诊医师分会,中华医学会急诊医学分会,全军急救医学专业委员会,中国急诊专科医联体,北京急诊医学学会.急性上消化道出血急诊诊治流程专家共识(2020版)[J].中华急诊医学杂志,2021,30(1):15-24.
[8] Fouad TR,Abdelsameea E,Abdel-Razek W,et al.Upper gastrointestinal bleeding in Egyptian patients with cirrhosis:post-therapeutic outcome and prognostic indicators[J].Gastroenterol Hepatol,2019,34(9):1604-1610.
[9] 张宁,谢元元.肝硬化患者血小板参数、门静脉宽度及凝血功能与上消化道出血关系的相关探讨[J].血栓与止血学,2021,27(5):801-802.
[10] Ding Y,Chen Q.The NF-κB pathway:a focus on inflammatory responses in spinal cord injury[J].Mol Neurobiol,2023,60(9):5292-5308.
[11] Duan Y,Chen J,Cui H,et al.The effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding[J].Am Transl Res,2021,13(5):5484-5490.
[12] 范子玲,辛克锋.凝血指标与血小板参数在肝硬化门静脉高压患者消化道出血中预测价值研究[J].临床军医杂志,2019,47(9):936-937.
[13] 苏小红,李静博.肝硬化患者血小板参数、凝血指标与上消化道出血的相关性[J].肝脏,2023,28(10):1171-1174.