Abstract：Objective: To analyze the levels of blood lipids and homocysteine (Hcy) in patients with subclinical hypothyroidism (SCH) and their relationship with thyroid-stimulating hormone (TSH). Methods: A total of 119 patients diagnosed with SCH between March 2020 and March 2023 were selected as the SCH group. Additionally, 121 healthy individuals with normal health examination indicators during the same period were selected as the normal control group. Blood lipid metabolism, Hcy, and TSH levels were compared between the SCH group and the normal control group. Within the SCH group, subgroup analysis (SCH1 and SCH2) based on TSH levels was conducted to compare lipid metabolism and Hcy levels. Correlation analysis using partial correlation coefficients and multiple linear regression were performed to assess the association between blood lipid metabolism, Hcy levels, and TSH levels. Results: Compared with the normal control group, the SCH group showed higher levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), Hcy, and TSH (P<0.05). There were no statistically significant differences in high-density lipoprotein cholesterol (HDL-C), free triiodothyronine (FT3), and free thyroxine (FT4) levels between the SCH group and the normal control group (P>0.05). Subgroup analysis within the SCH group revealed that TC, LDL-C, and Hcy levels were higher in SCH2 compared to SCH1 (P<0.05). There were no significant differences in TG, HDL-C, FT3, and FT4 levels between SCH1 and SCH2 (P>0.05). After adjusting for gender, age, BMI, smoking history, fasting plasma glucose (FPG), and TSH, multiple linear regression analysis indicated that TSH was a risk factor for abnormalities in TC, TG, LDL-C, and Hcy levels, while the linear regression relationship between TSH and HDL-C was not statistically significant(P>0.05). Conclusion: Patients with subclinical hypothyroidism exhibit alterations in blood lipid metabolism and Hcy levels, which are influenced by TSH levels. Therefore, monitoring blood lipid metabolism and Hcy levels in patients with subclinical hypothyroidism should be strengthened. This study provides a new perspective for clinicians to assess and manage cardiovascular risks in patients with subclinical hypothyroidism.
马望雯, 赵燕萍, 李文亚. 亚临床甲状腺功能减退症患者血脂和Hcy水平及其与TSH的关系分析[J]. 河北医学, 2024, 30(7): 1130-1134.
MA Wangwen, ZHAO Yanping, LI Wenya. Analysis of Lipid Profile and Homocysteine Levels in Subclinical Hypothyroidism Patients and Their Relationship with TSH. HeBei Med, 2024, 30(7): 1130-1134.
2024, Vol. 30 
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