Study on the Assessment of Fetal Growth Restriction and Pregnancy Outcome by Color Doppler Ultrasound Combined with Serum Pregnancy-Associated Plasma Protein A
SUN Tingting, CHEN Yun, LIU Xianxiang, et al
The 901st Hospital of People's Liberation Army Joint Logistic Support Force, Anhui Hefei 230031, China
Abstract：Objective: To explore the value of color Doppler ultrasound combined with serum pregnancy-associated protein A (PAPP-A) on evaluating fetal growth restriction (FGR) and pregnancy outcomes.Methods: The clinical data of 1465 pregnant women in the first trimester who were admitted to our hospital were retrospectively analyzed from May 2021 to May 2023. All patients underwent color Doppler ultrasound examination after enrollment, and serum PAPP-A was detected. According to the status of FGR, the patients were divided into restricted group (n=105) and normal group (n=1360). The ultrasound examination results and serum PAPP-A level were compared between the two groups. ROC curve was used to analyze the predictive efficiency of ultrasound examination and serum PAPP-A level at admission on FGR. By means of the pregnancy outcomes, the pregnant women in growth restriction group were classified into abnormal pregnancy outcome subgroup and normal delivery subgroup, and the ultrasound results and serum PAPP-A level were compared between the two subgroups. ROC curve was applied to analyze the predictive efficiency of ultrasound examination and serum PAPP-A level at admission on pregnancy outcomes.Results: The UtA-PI and UtA-RI in restricted group were significantly higher than those in normal group while serum PAPP-A level was significantly lower than that in normal group (P<0.05). ROC curve analysis showed that the AUCs of UtA-PI, UtA-RI and serum PAPP-A for predicting FGR were 0.759, 0.631 and 0.855 respectively (P<0.05). The UtA-PI and UtA-RI in abnormal pregnancy outcome subgroup were significantly higher while the level of serum PAPP-A was significantly lower compared to normal delivery subgroup (P<0.05). ROC curve analysis revealed that the AUCs of UtA-PI, UtA-RI and serum PAPP-A were 0.712, 0.692 and 0.658 respectively in predicting abnormal pregnancy outcomes (P<0.05).Conclusion: UtA-PI, UtA-RI values, and serum PAPP-A are closely related to the occurrence of fetal FGR and have high clinical value on predicting the pregnancy outcomes of pregnant women.
孙婷婷, 陈云, 刘贤香, 段性梅, 杨红艳. 彩色多普勒超声联合血清妊娠相关蛋白A评估胎儿生长受限及妊娠结局的研究[J]. 河北医学, 2024, 30(6): 987-991.
SUN Tingting, CHEN Yun, LIU Xianxiang, et al. Study on the Assessment of Fetal Growth Restriction and Pregnancy Outcome by Color Doppler Ultrasound Combined with Serum Pregnancy-Associated Plasma Protein A. HeBei Med, 2024, 30(6): 987-991.
2024, Vol. 30 
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