Abstract：Objective: To explore the value of serum miR-200c and pregnancy-associated plasma protein-A (PAPP-A) levels in combination with transvaginal ultrasound for the differential diagnosis of threatened abortion and ectopic pregnancy.Methods: This study was conducted from January 2020 to January 2022, including 43 cases of normal early pregnancy, 43 cases of ectopic pregnancy, and 43 cases of threatened abortion who visited our hospital during this period. All patients underwent transvaginal ultrasound examination, and various ultrasound parameters were recorded. The differences in serum miR-200c and PAPP-A levels at the time of consultation were compared among the groups to investigate their diagnostic value for threatened abortion and ectopic pregnancy.Results: There was no statistically significant difference in the average diameter of the corpus luteum among the three groups (P>0.05). The endometrial thickness in the ectopic pregnancy group was lower than that in the threatened abortion and normal early pregnancy groups, and the thickness in the threatened abortion group was lower than that in the normal early pregnancy group (P<0.05). The resistance index (RI) in the threatened abortion group was higher than that in the ectopic pregnancy and normal early pregnancy groups, and the RI in the ectopic pregnancy group was higher than that in the normal early pregnancy group (P<0.05). The peak systolic velocity (PSV) in both the threatened abortion and ectopic pregnancy groups was lower than that in the normal early pregnancy group (P<0.05), but there was no statistically significant difference between the threatened abortion and ectopic pregnancy groups (P>0.05). The serum miR-200c levels in the threatened abortion and ectopic pregnancy groups were higher than those in the normal early pregnancy group (P<0.05), but there was no statistically significant difference between the threatened abortion and ectopic pregnancy groups (P>0.05). The PAPP-A levels in the ectopic pregnancy group were lower than those in the threatened abortion and normal early pregnancy groups, and the levels in the threatened abortion group were lower than those in the normal early pregnancy group (P<0.05). Analysis showed that the specificity of combined ultrasound, miR-200c, and PAPP-A levels for diagnosing threatened abortion was higher than that of any single indicator, and the specificity and positive predictive value for diagnosing ectopic pregnancy were higher than those of any single indicator.Conclusion: The combination of serum miR-200c and PAPP-A levels with transvaginal ultrasound examination can effectively differentiate between threatened abortion and ectopic pregnancy, improving diagnostic accuracy and specificity, with significant clinical application potential.
郭彩萍, 陈艳梅, 马延玲. miR-200c PAPP-A水平与经阴道超声鉴别诊断先兆流产和异位妊娠的价值[J]. 河北医学, 2024, 30(6): 945-951.
GUO Caiping, CHEN Yanmei, MA Yanling. The Value of miR-200c and PAPP-A Levels Combined with Transvaginal Ultrasound in Differentiating Threatened Abortion and Ectopic Pregnancy. HeBei Med, 2024, 30(6): 945-951.
2024, Vol. 30 
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