Abstract：Objective: To investigate the hazard factors for severe low anterior resection syndrome(LARS) in patients with rectal cancer after low anterior resection. Methods: A total of 156 patients who underwent low anterior resection for rectal cancer at the Affiliated Hospital of Chengde Medical College from February 2019 to May 2021 were selected as the study subjects. The patients were evaluated postoperatively by telephone follow-up and outpatient visits, and the LARS score was calculated. Univariate and multivariate logistic regression analyses were used to explore the factors influencing the occurrence of severe LARS. Results: Among the 156 patients,69 cases (44.23%) developed LARS, including 34 cases of mild LARS (21.79%) and 35 cases of severe LARS (22.44%). Univariate analysis indicated that neoadjuvant radiotherapy, obesity, height of anastomosis to tooth line(≤2cm), and stomal leak after operation were closely related to severe LARS. Multivariate regression analysis showed that preoperative neoadjuvant radiotherapy, anastomosis-to-dentate line height less than 2cm, BMI ≥ 25kg/m2, and postoperative anastomotic leakage were closely related to the occurrence of severe LARS.Conclusion: Patients with low anterior resection have a higher risk of LARS. Obesity, neoadjuvant radiotherapy, anastomosis distance less than 2cm, and postoperative anastomotic leakage are independent risk factors for severe LARS.
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2024, Vol. 30 
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