高胆红素血症新生儿血清CKMB NPY及β<sub>2</sub>-MG的水平变化及临床意义

doi:10.3969/j.issn.1006-6233.2024.06.08

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摘要 目的: 探讨高胆红素血症新生儿血清肌酸激酶同工酶(CreatineKinase-MB,CKMB)、神经肽Y(Neuropeptide Y,NPY)及β₂-微球蛋白(β₂-microglobulin,β₂-MG)的水平变化及临床意义。方法: 选取本院2019年1月至2022年1月收治的高胆红素血症新生儿118例为观察组,根据总胆红素(total bilirubin,STB)分度分为:轻度组58例(220.6μmoL/L<STB≤256.5μmoL/L),中度组42例(256.5μmoL/L<STB≤342μmoL/L),重度组18例(STB>342μmoL/L);另选取同期于本院经皮胆红素测定无黄疸的健康新生儿112例为对照组。比较对照组、观察组CKMB、NPY及β₂-MG水平;比较观察组不同STB程度患者CKMB、NPY及β₂-MG水平;根据经皮胆红素测定的STB水平分为急性期组及恢复期组,比较急性期及恢复期两组患者CKMB、NPY及β₂-MG水平。结果: 观察组CKMB、NPY及β₂-MG水平均比对照组高(P<0.05)。不同STB程度患者CKMB、NPY、β₂-MG水平比较:轻度组<中度组<重度组(P<0.05)。118例高胆红素血症新生儿中,急性期组67例和恢复期组51例,急性期组CKMB、NPY、β₂-MG水平均高于恢复期组(P<0.05)。结论: 血清CKMB、NPY及β₂-MG与高胆红素血症新生儿病情严重程度及预后关系密切,可通过检测上述指标评估患儿病情进展及预后,具有重要临床意义。

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关键词 ：肌酸激酶同工酶, 神经肽Y, β₂-微球蛋白, 高胆红素血症, 新生儿

Abstract：Objective: To investigate the changes and clinical significance of serum creatine kinase isoenzyme (CreatineKinase-MB, CKMB), neuropeptide Y (Neuropeptide Y, NPY), and β₂-microglobulin (β₂-microglobulin, β₂-MG) levels in hyperbilirubinemic neonates.Methods: A total of 118 hyperbilirubinemic neonates admitted to our hospital from January 2019 to January 2022 were selected as the observation group. According to the total bilirubin (STB) level, they were divided into three groups: mild group (n=58, 220.6μmol/L≤STB≤256.5μmol/L), moderate group (n=42,256.5μmol/L≤STB≤342μmol/L), and severe group (n=18, STB>342μmol/L). Another 112 healthy neonates without jaundice who underwent percutaneous bilirubin measurement in our hospital during the same period were selected as the control group. The levels of CKMB, NPY, and β₂-MG in the control group and observation group were compared. The levels of CKMB, NPY, and β₂-MG in patients with different STB levels in the observation group were compared. According to the percutaneous bilirubin-measured STB level, the patients were divided into the acute phase group and the recovery phase group, and the levels of CKMB, NPY, and β₂-MG in the two groups were compared.Results: The levels of CKMB, NPY, and β₂-MG in the observation group were all higher than those in the control group (P<0.05). Comparison of CKMB, NPY, and β₂-MG levels in patients with different STB levels: mild group < moderate group < severe group (P<0.05). Among the 118 hyperbilirubinemic neonates, there were 67 cases in the acute phase group and 51 cases in the recovery phase group. The levels of CKMB, NPY, and β₂-MG in the acute phase group were all higher than those in the recovery phase group (P<0.05).Conclusion: Serum CKMB, NPY, and β₂-MG levels are closely related to the severity and prognosis of hyperbilirubinemia in neonates. Monitoring these indicators can help assess the progression and prognosis of the condition, providing significant clinical value.

Key words： Creatine kinase isoenzyme Neuropeptide Y β₂-microglobulin Hyperbilirubinemia Palingenesis

基金资助:黑龙江省卫生计生委科研课题,(编号:2018220)

通讯作者: 张冉

引用本文:

李佳强, 袁迅玲, 张冉, 沈书, 田玲玲. 高胆红素血症新生儿血清CKMB NPY及β₂-MG的水平变化及临床意义[J]. 河北医学, 2024, 30(6): 923-927.
LI Jiaqiang, et al. Changes and Clinical Significance of Serum Creatine Kinase MB Neuropeptide Y and β₂-Microglobulin Levels in Hyperbilirubinemic Neonates. HeBei Med, 2024, 30(6): 923-927.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.06.08 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I6/923

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