Abstract：Objective: To investigate the relationship between serum interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels and the prognosis of neonatal sepsis. Methods: A total of 86 neonates with sepsis admitted to our hospital from August 2020 to March 2023 were enrolled as the study subjects. The general data of the cured/improved group and the death group were analyzed. The serum IL-6, PCT, and CRP levels of the neonates in the two groups at different time points were compared, and the factors affecting the prognosis of neonates with sepsis were analyzed. Results: Among the 86 neonates with sepsis, there were 77 neonates in the cured/improved group and 9 neonates in the death group (4 neonates died within 12 hours, 2 died within 2 days, 2 died within 3 days, and 1 died within 5 days). The percentages of IL-6 > 7 pg/mL, PCT > 0.5 ng/mL, and CRP > 10 mg/mL in the death group were higher than those in the cured/improved group at 12 hours, 12-36 hours, and 7 days after onset (P < 0.05). There were no statistically significant differences in gender, premature rupture of membranes, preterm birth, jaundice, and delivery method between the two groups (P > 0.05). The gestational age, birth weight, and Ages & Stages Questionnaires (ASQ) at 0-6 years old were significantly different between the two groups (P < 0.05). Multivariate logistic regression analysis showed that ASQ at 0-6 years old, IL-6, PCT, and CRP were independent risk factors for the prognosis of neonatal sepsis (P < 0.001). Conclusion: Serum IL-6, PCT, and CRP levels are related factors affecting the prognosis of neonates with sepsis. Monitoring serum IL-6, PCT, and CRP levels may provide reliable references for clinical adjustment of treatment strategies for neonatal sepsis.
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2024, Vol. 30 
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