Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of AECOPD Combined with Hypercapnia and Its Effect on Blood Gas Analysis and Inflammatory Factors
GUAN Wenxia, JIN Jianfeng, MA Xiaojun
Linfen Central Hospital, Shanxi Linfen 041000, China
Abstract：Objective: To analyze the clinical efficacy of non-invasive mechanical ventilation (NIV) in the treatment of AECOPD combined with hypercapnia and its effect on blood gas analysis, inflammation factors. Methods: A retrospective analysis was conducted on 118 patients with AECOPD combined with hypercapnia treated in our hospital from April 2022 to April 2023, 58 cases were divided into control group (oxygen therapy and conventional drug treatment) and 60 cases were divided into observation group (NIV treatment). The clinical efficacy, blood gas analysis (pH, PaO2, PaCO2), Inflammatory factors (IL-6, IL-10,TNF-α) and T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+). Results: The total effective rate of the control group (63.79%) was lower than that of the observation group (81.67%) (P<0.05); the differences in PaO2, pH, and PaCO2 before treatment between the two groups were not statistically significant (P > 0.05). Comparison of the differences in PaO2, pH, PaCO2 before and after treatment between the two groups (P>0.05); Comparison of the levels of IL-6, IL-10, TNF-α before treatment between the two groups (P>0.05); The difference in IL-6, IL-10, TNF-α before and after treatment in the observation group was greater than that in the control group (P<0.05); Comparison of the levels of CD3+, CD4+, CD4+/CD8+ before treatment between the two groups (P<0.05); Comparison of the levels of CD3+, CD4+, CD4+/CD8+ before treatment between the two groups (P<0.05). levels were compared (P>0.05); the difference between CD3+, CD4+, CD4+/CD8+ before and after treatment in the observation group was greater than that in the control group (P<0.05). Conclusion: NIV treatment improves the clinical therapeutic effect of AECOPD patients with hypercapnia, effectively improves inflammatory factor indexes and T lymphocyte subsets, and contributes to the comprehensive recovery of patients.
关文霞, 靳建峰, 马小军. 无创机械通气治疗慢性阻塞性肺疾病急性加重期合并高碳酸血症临床疗效及对血气分析炎性因子的影响[J]. 河北医学, 2024, 30(4): 593-597.
GUAN Wenxia, JIN Jianfeng, MA Xiaojun. Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of AECOPD Combined with Hypercapnia and Its Effect on Blood Gas Analysis and Inflammatory Factors. HeBei Med, 2024, 30(4): 593-597.
[1] 王欣宇,马晶晶,贾睿奕,等.COPD并发肺动脉高压患者血清OPG水平的变化及临床意义[J].西部医学,2023,38(1):121-124,129. [2] De Araujo,Bruna Espindola,Kowalski,et al.AND-ASPEN and ESPEN consensus,and GLIM criteria for malnutrition identification in AECOPD patients:a longitudinal study comparing concurrent and predictive validity[J].European Journal of Clinical Nutrition,2022,76(5):685-692. [3] 王洪武,黄琳惠,蔡兴俊,等.有创-无创序贯机械通气治疗AECOPD合并Ⅱ型呼吸衰竭患者的临床疗效及影响因素[J].山东医药,2020,60(13):79-82. [4] 杜璐玲,陈建永,李少明.无创机械通气对AECOPD合并高碳酸血症患者治疗前后炎症状态及T淋巴细胞亚群的影响[J].广西医科大学学报,2022,39(1):142-146. [5] 慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组.慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2014年修订版)[J].国际呼吸杂志,2014,34(1):1-11. [6] 吴迪,杨凯,陈荣昌.慢性阻塞性肺疾病急性加重机械通气方式变化趋势及其疗效[J].广东医学,2020,41(7):677-682. [7] 唐丹丹,黄远东.降钙素原和炎症因子在COPD急性加重期病原鉴别诊断中的价值[J].内蒙古医学院学报,2020,42(3):292-295. [8] 潘彬,孙建,郑鹏城,等.血清TK1、PCT、IL-6水平在AECOPD患者中的表达及其意义[J].标记免疫分析与临床,2020,27(7):1121-1124,1129. [9] Luchytskiy E V,Luchytskiy V E,Zubkova G A,et al.Blood concentrations of endothelin,interleukins 6 and 10 in men with diabetes mellitus[J].International Journal of Endocrinology (Ukraine),2021,17(4):280-286. [10] 黄颖骏,秦斌斌,沈斌,等.血清炎性因子联合检测在慢性阻塞性肺疾病急性加重期患者病情评估中的临床应用价值[J].中国医药,2022,17(3):399-402. [11] 马小玉,安福成,李鹏飞.AECOPD患者肺部感染病原学特点及辅助性T细胞亚群检测价值分析[J].热带医学杂志,2022,22(12):1692-1695,1710. [12] 赵萌,赵育周,赵志娟,等.T淋巴细胞亚群在慢性阻塞性肺疾病发生发展中的作用研究进展[J].检验医学与临床,2023,20(5):705-709.
2024, Vol. 30 
冀公网安备13080202000677号