Abstract：Objective: To investigate the role of signal transducer and activator of transcription 3 (STAT3) polymorphism in the development of cervical cancer caused by human papillomavirus 16 (HPV16). Methods: A retrospective study was conducted on 34 patients with cervical cancer who were admitted to the hospital from 2019 to 2023. They were assigned to Group A. Another 54 patients with cervical intraepithelial neoplasia and 80 patients with chronic cervicitis admitted to the hospital during the same period were assigned to Groups B and C, respectively. The expression of HPV16 E6 protein was detected by immunohistochemistry and polymerase chain reaction (PCR)-reverse dot blot hybridization. The expression of STAT3 protein was detected by PCR, and the polymorphism of STAT3 gene C1697G was detected by PCR-restriction fragment length polymorphism (RFLP). The expression rates of E6 and STAT3 proteins and the genotypes of STAT3 gene polymorphism in the three groups were compared and analyzed. Results: The positive expression rates of E6 and STAT3 proteins in Group A were significantly higher than those in Groups B and C (P<0.0167). The positive expression rates of E6 and STAT3 proteins in Group B were significantly higher than those in Group C (P<0.0167). The frequency of the G/G genotype in Groups A and B was significantly lower than that in Group C, and the frequency of the C/C genotype was significantly higher than that in Group C (P<0.0167). The frequency of the G/G genotype in Group A was significantly lower than that in Group B, and the frequency of the C/C genotype was significantly higher than that in Group B (P<0.0167). There was no significant difference in the frequency of the G/C genotype among the three groups (P>0.0167). Conclusion: STAT3 and its polymorphism may play an important role in the development and progression of cervical cancer caused by HPV16.
张荷敏, 余燕, 刘艳筠. STAT3的多态性在HPV16所致宫颈癌发生中的作用[J]. 河北医学, 2024, 30(4): 560-564.
ZHANG Hemin, YU Yan, LIU Yanyun. The Role of STAT3 Polymorphism in the Development of Cervical Cancer Caused by HPV16. HeBei Med, 2024, 30(4): 560-564.
2024, Vol. 30 
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