Abstract：Objective: To explore the effects of rocuronium-sugammadex and rocuronium-neostigmine reversal strategies on pulmonary function in patients undergoing lobectomy. Methods: Eighty-six patients who underwent lobectomy from January 2021 to December 2022 were selected as the research subjects. They were randomly divided into an observation group (receiving rocuronium-sugammadex reversal strategy) and a control group (receiving rocuronium-neostigmine reversal strategy), with 43 cases in each group. The forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEFR), norepinephrine (NE), propofol (Cor), blood oxygen pressure (PaO2), remifentanil dose, oxygenation index (PaO2/FiO2), postoperative autonomous breathing recovery time, postoperative consciousness recovery time, muscle relaxant onset time, extubation time, post-anesthesia care unit (PACU) stay time, and postoperative complications were compared between the two groups. Results: Repeated measures analysis of variance showed that there were significant time effects, group effects, and time-group interaction effects in FEV1, FVC, PEFR, NE, Cor, PaO2, and PaO2/FiO2 in both groups (P<0.05). At the time points of tracheal extubation and removal of chest drainage tube, the FEV1, FVC, and PEFR in the observation group were higher than those in the control group (P<0.05). At T1, T2, and T3 time points, NE and Cor in the observation group were lower than those in the control group (P<0.05). At the time of skin incision, 15 minutes before extubation, and immediately after leaving the PACU, PaO2 and PaO2/FiO2 in the observation group were higher than those in the control group (P<0.05). The propofol and remifentanil doses in the observation group were lower than those in the control group, and the postoperative autonomous breathing recovery time, PACU stay time, postoperative consciousness recovery time, muscle relaxant onset time, and extubation time were shorter than those in the control group (P<0.05). The incidence of nausea and vomiting, chills, hypotension, and pulmonary complications on postoperative days 1 and 7 in the observation group was lower than that in the control group (P<0.05). Conclusion: The use of rocuronium-sugammadex for muscle relaxation reversal in patients undergoing lobectomy is beneficial for reducing the impact on pulmonary function and lowering the incidence of postoperative complications.
郭宇东, 马晓燕, 李文娟, 申彦杰, 胡美玲. 舒更葡糖钠与新斯的明肌松拮抗策略对肺叶切除患者肺功能影响效果分析[J]. 河北医学, 2024, 30(2): 250-254.
GUO Yudong, MA Xiaoyan, LI Wenjuan, et al. Effect Analysis of Antagonistic Strategy of Shugeng Sodium Gluconate and Neostigmine on Lung Function in Patients Undergoing Lobectomy. HeBei Med, 2024, 30(2): 250-254.
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2024, Vol. 30 
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