载药微球经动脉化疗栓塞对比碘油栓塞治疗中晚期肝癌的有效性及安全性分析

doi:10.3969/j.issn.1006-6233.2023.12.021

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摘要 目的: 分析载药微球经动脉化疗栓塞术(DEB-TACE)对比常规经动脉化疗栓塞术(cTACE)在中晚期肝癌中的应用价值。方法: 对2018年3月至2021年3月期间我院中晚期肝癌患者进行回顾性分析,根据治疗方法进行分组,其中92例实施DEB-TACE术(纳入DEB-TACE组),125例实施cTACE术(纳入cTACE组),比较两组疗效和安全性。结果: DEB-TACE组术后1个月疾病缓解率高于cTACE组,手术前后TBIL、ALT、AST、AFP差值大于cTACE组,术后呕吐反应严重程度轻于cTACE组,预后1年生存率高于cTACE组(P<0.05)。结论: DEB-TACE治疗中晚期肝癌疗效更优,且并发症更少、安全性更高。

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关键词 ：载药微球经动脉化疗栓塞术, 经动脉化疗栓塞术, 肝癌, 中晚期

Abstract：Objective: To analyze the application value of drug-eluting microsphere transarterial chemoembolization (DEB-TACE) compared with conventional transarterial chemoembolization (cTACE) in intermediate to advanced hepatocellular carcinoma. Methods: A retrospective analysis was conducted on patients with intermediate to advanced hepatocellular carcinoma in our hospital from March 2018 to March 2021. The patients were grouped according to the treatment method, with 92 cases undergoing DEB-TACE (included in the DEB-TACE group) and 125 cases undergoing cTACE (included in the cTACE group). The efficacy and safety of the two groups were compared. Results: The disease remission rate in the DEB-TACE group was higher than that in the cTACE group at 1 month after surgery. The differences in TBIL, ALT, AST, and AFP before and after surgery were greater in the DEB-TACE group than in the cTACE group. The severity of postoperative vomiting was lower in the DEB-TACE group than in the cTACE group. The one-year survival rate was higher in the DEB-TACE group than in the cTACE group (P<0.05). Conclusion: DEB-TACE treatment is more effective for intermediate to advanced hepatocellular carcinoma, with fewer complications and higher safety.

Key words： Drug-eluting beads transarterial chemoembolization Transcatheter arterial chemoembolization Liver cancer Middle-to-advanced stage

基金资助:江苏省2020年省基础研究计划自然科学基金项目,(编号:BK20200192);中国健康促进基金会“肿瘤介入科研基金”,(编号:XM_2018_011_0006_01)

通讯作者: 王玲玲

引用本文:

梁黎, 丁文彬, 徐管梅, 钱静, 江晓冬, 王玲玲. 载药微球经动脉化疗栓塞对比碘油栓塞治疗中晚期肝癌的有效性及安全性分析[J]. 河北医学, 2023, 29(12): 2049-2054.
LIANG Li, DING Wenbin, XU Guanmei, et al. Effectiveness and Safety Analysis of Drug-Eluting Microsphere Transarterial Chemoembolization Compared with Conventional Transarterial Chemoembolization in the Treatment of Intermediate to Advanced Hepatocellular Carcinoma. HeBei Med, 2023, 29(12): 2049-2054.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.12.021 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I12/2049

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