Abstract：Objective: To explore the diagnostic accuracy of CT-guided percutaneous transthoracic needle biopsy (PTNB) for non-small cell lung cancer (NSCLC) and its influencing factors. Methods: A total of 98 patients with NSCLC treated in the hospital were enrolled as the research subjects between May 2020 and May 2022. All underwent PTNB. Taking the results of postoperative pathological examination as the golden standard, diagnostic results of PTNB for NSCLC were statistically analyzed, and the influencing factors of diagnostic accuracy were analyzed. Results: The diagnostic accuracy of PTNB for NSCLC was 87.76% (86/98), and the accuracy rates of adenocarcinoma, squamous cell carcinoma, large cell carcinoma and adenosquamous carcinoma were 91.53% (54/59), 93.94% (31/33), 0.00% (0/2) and 25.00% (1/4), respectively. The results of univariate analysis showed that there was no significant difference in gender, age, calcification, size of biopsy tissues or biopsy frequency between accuracy group and non-accuracy group (P>0.05), but there were significant differences in lesion sites, lesion size, distance between lesion and chest walls, necrosis and puncture depth (P<0.05). The results of multivariate analysis showed that lesions at inferior lobe, lesion <2cm, the distance between lesions and chest walls <2cm and necrosis were independent influencing factors of diagnostic accuracy rate. Conclusion: PTNB has high diagnostic value for adenocarcinoma and squamous cell carcinoma, but has low diagnostic value for large cell carcinoma and adenosquamous carcinoma. The independent influencing factors of diagnostic accuracy rate include lesions at inferior lobe, lesions <2cm, the distance between lesions and chest walls <2cm and necrosis. Targeted measures is beneficial to increase diagnostic accuracy rate.
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2023, Vol. 29 
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