Abstract：Objective: To explore the value of contrast-enhanced ultrasound (CEUS) combined with serum tumor markers in the early diagnosis of endometrial carcinoma (EC). Methods: A total of 120 patients with early EC treated in the hospital were enrolled as the research objects between October 2021 and February 2022, while 120 patients undergoing hysteromyoma excision during the same period were enrolled as control group. All underwent transvaginal sonography contrast-enhanced ultrasonography (TVS-CEUS) examination. Taking pathological diagnosis as the golden standard, diagnostic efficiency of CEUS for EC was analyzed. The peripheral blood was collected to detect levels of carbohydrate antigen 125 (CA125) and vascular endothelial growth factor (VEGF). The relative expression levels of serum microRNA-125a (miR-125a) and miR-200a were detected by qRT-PCR. The correlation between CA125, VEGF and miR-125a, miR-200a was analyzed. The diagnostic efficiency of CEUS combined with CA125, VEGF, miR-125a and miR-200a for EC was evaluated by receiver operating characteristic (ROC) curves. Results: The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and kappa value of TVS-CEUS in the early diagnosis of EC were 81.67%, 71.67%, 76.67%, 74.24%, 79.63%, and 0.533, respectively. The levels of serum CA125 and VEGF, and relative expression level of miR-200a in EC group were higher than those in control group, while relative expression level of miR-125a was lower than that in control group (P<0.05). The results of Pearson correlation analysis showed that levels of serum CA125 and VEGF were negatively correlated with relative expression level of miR-125a (P<0.05), while positively correlated with relative expression level of miR-200a (P<0.05). The result of ROC curve analysis showed that AUC of TVS-CEUS combined with CA125, VEGF, miR-125a, and miR-200a in the early diagnosis of EC was significantly greater than that of CA125, VEGF, miR-125a, and miR-200a alone (P<0.05). Conclusion: TVS-CEUS combined with serum tumor markers has high early diagnostic efficiency for EC, which can provide reference for condition evaluation of patients.
孙宏伟, 李丽娟, 龚雪. 超声造影联合血清CA125 VEGF miR-125a miR-200a对早期诊断子宫内膜癌的诊断价值观察[J]. 河北医学, 2023, 29(9): 1549-1553.
SUN Hongwei, LI Lijuan, et al. Value of Contrast-Enhanced Ultrasound Combined with Serum CA125 VEGF miR-125a and miR-200a in the Early Diagnosis of Endometrial Carcinoma. HeBei Med, 2023, 29(9): 1549-1553.
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2023, Vol. 29 
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