血清SCC M-CSF Chemerin水平对宫颈上皮内瘤变患者诊断评估价值

doi:10.3969/j.issn.1006-6233.2023.09.08

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摘要 目的: 探讨宫颈上皮内瘤变患者血清鳞状细胞癌抗原(SCC)、巨噬细胞集落刺激因子(M-CSF)、趋化素(Chemrin)的变化及其诊断学价值。方法: 选取我院2019年4月至2022年4月经病理学检查确诊的101例宫颈上皮内瘤变(CIN)患者作为CIN组、同期经病理学检查证实为早期宫颈癌患者50例作为宫颈癌组,对比两组患者实施治疗之前的血清SCC、M-CSF、Chemerin测定值,并根据CIN分期、高危人乳头状瘤病毒(HR-HPV)病毒载量检查结果进行分层对比分析,并对比CIN患者在手术前、手术后3个月血清SCC、M-CSF、Chemerin水平;采用受试者工作特征曲线(ROC)分析SCC、M-CSF、Chemerin在鉴别诊断CIN及早期宫颈癌中的应用价值。结果: 宫颈癌组患者的血清SCC、M-CSF、Chemerin测定值高于CIN组患者,差异具有统计学意义(P<0.05);SCC、M-CSF、Chemerin鉴别诊断CIN患者的ROC曲线下面积分别为0.906、0.846、0.791;101例CIN患者中有Ⅰ期患者21例、Ⅱ期患者46例、Ⅲ期患者34例,随着CIN分期的增高,患者的SCC、M-CSF、Chemerin水平逐渐增高,各组之间差异具有统计学意义(P<0.05);HR-HPV DNA阳性CIN患者的SCC、M-CSF测定值高于阴性组患者,各组之间差异具有统计学意义(P<0.05);在手术后3个月,CIN患者的SCC、M-CSF、Chemerin测定值均呈的降低趋势,差异具有统计学意义(P<0.05)。结论: 与宫颈癌患者相比,CIN患者的SCC、M-CSF、Chemerin测定值更低,但是随着CIN分级增高、HR-HPV DNA阳性表达患者的SCC、M-CSF、Chemerin水平更高,检查SCC、M-CSF、Chemerin水平能鉴别诊断CIN与宫颈癌。

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	孙莉
	宋玉荣
	胡频
	傅柳陶

关键词 ：宫颈上皮瘤变, 鳞状细胞癌抗原, 巨噬细胞集落刺激因子, 趋化素

Abstract：Objective: To investigate the changes of serum squamous cell carcinoma antigen (SCC), macrophage colony stimulating factor (M-CSF), and chemokine (Chemrin) in patients with cervical epithelial neoplasia and their diagnostic value. Methods: A total of 101 patients with cervical epithelial neoplasia (CIN) confirmed by pathological examination in our hospital from April 2019 to April 2022 were selected as the CIN group, and 50 patients with early cervical cancer confirmed by pathological examination in the same period were selected as the cervical cancer group. The measured values of serum SCC, M-CSF, and Chemerin before treatment were compared between the two groups, and the hierarchical comparative analysis was carried out according to the CIN stage and the results of high-risk human papillomavirus (HR-HPV) viral load test. The levels of serum SCC, M-CSF and Chemerin in CIN patients before and 3 months after operation were compared. The application value of SCC, M-CSF and Chemerin in the differential diagnosis of CIN and early cervical cancer was analyzed by the subject working characteristic curve (ROC). Results: The measured values of serum SCC, M-CSF and Chemerin in patients with cervical cancer were significantly higher than those in patients with CIN (P<0.05). The areas under ROC curve of SCC, M-CSF and Chemerin were 0.906, 0.846 and 0.791, respectively. Among the 101 patients with CIN, there were 21 patients with stage I, 46 patients with stage II, and 34 patients with stage III. With the increase of CIN stage, the levels of SCC, M-CSF, and Chemerin in the patients increased gradually, and the difference between the groups was statistically significant (P<0.05). The measured values of SCC and M-CSF in patients with HR-HPV DNA positive CIN were higher than those in patients with negative CIN, and the difference between the groups was statistically significant (P<0.05). Three months after the operation, the measured values of SCC, M-CSF and Chemerin in CIN patients showed a significant downward trend, and the difference was statistically significant (P<0.05). Conclusion: Compared with cervical cancer patients, the determination values of SCC, M-CSF and Chemerin in CIN patients were lower, but with the increase of CIN grading and the higher levels of SCC, M-CSF and Chemerin in patients with positive expression of HR-HPV DNA, Detection of SCC, M-CSF and Chemerin levels can differentiate CIN from cervical cancer.

Key words： Cervical epithelial neoplasia Squamous cell carcinoma antigen Macrophage colony stimulating factor Chemokinin

基金资助:2020年度安徽省自然科学基金项目,(编号:2008085QD162)

引用本文:

孙莉, 宋玉荣, 胡频, 傅柳陶. 血清SCC M-CSF Chemerin水平对宫颈上皮内瘤变患者诊断评估价值[J]. 河北医学, 2023, 29(9): 1447-1451.
SUN Li, SONG Yurong, HU Pin, et al. Diagnostic Value of Serum SCC M-CSF and Chemerin Levels in Patients with Cervical Intraepithelial Neoplasia. HeBei Med, 2023, 29(9): 1447-1451.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.09.08 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I9/1447

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