颈动脉超声参数结合血浆小而密低密度脂蛋白评估糖尿病患者动脉粥样硬化性心血管疾病的临床价值

doi:10.3969/j.issn.1006-6233.2023.08.021

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摘要 目的: 探究颈动脉超声参数结合血浆小而密低密度脂蛋白(sd-LDL)评估糖尿病患者动脉粥样硬化性心血管疾病(ASCVD)的临床价值。方法: 回顾性分析医院于2022年7月至2022年12月收治的104例糖尿病患者临床资料,将单纯性糖尿病患者纳入对照组(n=51),合并有ASCVD的患者纳入观察组(n=53),比较两组颈动脉超声参数以及sd-LDL,采用Logistic回归分析糖尿病患者ASCVD的影响因素并探究颈动脉超声参数与sd-LDL对评估糖尿病患者ASCVD的临床价值。结果: 观察组颈动脉超声参数:颈动脉内中膜厚度(IMT)、斑块积分均高于对照组,sd-LDL水平高于对照组(P<0.05);两组吸烟人数比较差异具有统计学意义(P<0.05);其余临床资料比较差异无统计学意义(P>0.05);Logistic多因素回归分析,结果显示:IMT、斑块积分、sd-LDL水平为糖尿病患者合并ASCVD的影响因素(P<0.05)。结论: 颈动脉超声参数以及sd-LDL在评估糖尿病患者ASCVD中具有较高临床价值,临床可联合颈动脉超声参数中的IMT、斑块积分及sd-LDL水平对ASCVD进行初步评估,为临床诊断与治疗ASCVD提供依据。

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关键词 ：糖尿病, 动脉粥样硬化性心血管疾病, 颈动脉超声参数, 血浆小而密低密度脂蛋白

Abstract：Objective: To investigate the clinical value of carotid artery ultrasound parameters combined with plasma small and dense low-density lipoprotein (sd-LDL) in evaluating atherosclerotic cardiovascular disease (ASCVD) in diabetic patients. Methods: The clinical data of 104 diabetic patients admitted to the hospital from July to December 2022 were analyzed retrospectively. Patients with simple diabetes were defined as the control group (n=51) and those with ASCVD were defined as the observation group (n=53). Carotid artery ultrasound parameters and sd-LDL were compared between groups. Logistic regression analysis was performed to screen the influencing factors of ASCVD in diabetic patients. The clinical value of carotid artery ultrasound parameters and sd-LDL in evaluating ASCVD in diabetic patients was discussed. Results: Carotid artery ultrasound parameters (carotid intima-media thickness (IMT) and plaque score) and sd-LDL level in the observation group were larger/higher than the control group (P<0.05). The numbers of smokers in the two groups were close (P<0.05). Logistic regression analysis found that IMT, plaque score and sd-LDL level were influencing factors of ASCVD in diabetic patients (P<0.05). Conclusion: Carotid artery ultrasound parameters and sd-LDL are much helpful for evaluating ASCVD in diabetic patients. Clinically, combination of IMT and plaque score and sd-LDL level can be adopted to provide a basis for clinical diagnosis and treatment of ASCVD.

Key words： Diabetes Atherosclerotic cardiovascular disease Carotid artery ultrasound parameter Plasma small and dense low-density lipoprotein

基金资助:山西省卫生健康委科研课题,(编号:2020160)

通讯作者: 闫炜

引用本文:

孙晓婷, 郭丹, 范瑞龙, 闫炜. 颈动脉超声参数结合血浆小而密低密度脂蛋白评估糖尿病患者动脉粥样硬化性心血管疾病的临床价值[J]. 河北医学, 2023, 29(8): 1340-1344.
SUN Xiaoting, et al. Clinical Value of Carotid Artery Ultrasound Parameters Combined with Plasma Small and Dense Low-Density Lipoprotein in Evaluating Atherosclerotic Cardiovascular Disease in Diabetic Patients. HeBei Med, 2023, 29(8): 1340-1344.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.08.021 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I8/1340