Abstract:Objective: To investigate the effects of dagliprazin combined with glucagon-like peptide-1 (GLP-1) analogs on blood glucose fluctuation and ventricular remodeling in patients with diabetes mellitus and chronic heart failure. Methods: Ninety diabetic patients with chronic heart failure were randomly divided into two groups. The patients in the control group were treated with GLP-1 analogues, and the patients in the study group were treated with dapagliflozin combined with GLP-1 analogues. The efficacy, blood glucose fluctuation and ventricular remodeling were compared between the two groups. Results: Compared with the control group, the overall response rate was higher in the study group (P<0.05); before and after treatment, glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2h postprandial plasma glucose (2hPG) levels, amplitude of blood glucose excursion (LAGE), mean absolute difference of daytime blood glucose (MODD), amplitude of postprandial blood glucose excursion (PPGE), standard deviation of blood glucose level (SDBG), left ventricular remodeling index (LVRI), left ventricular mass index (LVMI), left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) differences were greater in the study group than in the control group (P<0.05). Conclusion: Dapagliflozin combined with GLP-1 analogues can reduce blood glucose fluctuation and improve ventricular remodeling in diabetic patients with chronic heart failure.
芦秋彤, 常欣, 巴丽丽, 柏静. 达格列净联合胰高糖素样肽-1类似物在糖尿病伴慢性心衰中的治疗效果观察[J]. 河北医学, 2023, 29(8): 1308-1312.
LU Qiutong, CHANG Xin, BA Lili, et al. Therapeutic Effect of Dagliflozin Combined with Glucagon-Like Peptide-1 Analog in Diabetes Mellitus with Chronic Heart Failure. HeBei Med, 2023, 29(8): 1308-1312.
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