Abstract：Objective: To explore the value comparison of fine needle biopsy (US-FNA) and crude needle biopsy (US-CNB) in the diagnosis of different size thyroid nodules. Methods: A total of 106 patients with thyroid nodules admitted to our hospital from March 2020 to March 2022 were selected and grouped according to the maximum diameter of the nodule, Patients with a nodule diameter less than 10mm were included in group A and the maximum diameter more then 10mm was included in Group B. All patients were examined for US-FNA and US-CNB, and postoperative pathological diagnosis was performed. Postoperative pathological diagnosis was taken as the gold standard to explore the value of US-FNA and US-CNB in the diagnosis of thyroid nodules of different sizes. Results: There were 37 malignant nodules (2 follicular carcinomas, 28 papillary carcinomas, 3 thyroid lymphomas, and 4 thyroid sarcomas) and 13 benign nodules (2 nodular goiters with follicular adenomatous nodules, and 11 nodular goiters) in patients in group A. There were 39 malignant nodules (3 follicular carcinoma, 31 papillary carcinoma, 2 thyroid lymphoma, 3 thyroid sarcoma) and 17 benign nodules (4 nodular goiter with follicular adenoma nodules, 13 nodular goiter) in patients in group B. The accuracy of diagnosis of thyroid nodules by US-CNB and US-FNA in patients in group A was 80.00% and 82.00%, sensitivity was 86.49% and 83.78%, specificity was 61.54% and 76.92%, positive predictive value was 86.49% and 91.18%, negative predictive value was 61.54% and 62.50%, and kappa Consistency test analyzed kappa values were 0.480 (P=0.001), 0.565 (P<0.001) respectively. The accuracy of diagnosis of thyroid nodules by US-FNA and US-CNB in patients in group B was 73.21% and 78.57%, the sensitivity was 76.92% and 79.49%, the specificity was 64.71% and 76.47%, the positive predictive value was 83.33% and 88.57%, and the negative predictive value was 55.00% and 61.90%, respectively, and the kappa Consistency test was analyzed and the kappa values were 0.525 (P<0.001), 0.397 (p=0.003), respectively. Conclusion: When the patient's thyroid nodule is less then10 mm, US-FNA is chosen for diagnosis with high accuracy; when it is more 10 mm, US-CNB should be chosen for diagnosis.
辛敏慧, 张植兰, 李忠举. US-FNA与US-CNB在不同大小甲状腺结节诊断中的价值比较[J]. 河北医学, 2023, 29(8): 1298-1302.
XIN Minhui, ZHANG Zhilan, LI Zhongju. Comparison of the Value of US-FNA and US-CNB in the Diagnosis of Thyroid Nodules of Different Sizes. HeBei Med, 2023, 29(8): 1298-1302.
2023, Vol. 29 
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