Abstract：Objective: To investigate the value of apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) sequence in differentiating benign and malignant focal lesions of the prostate. Methods: A total of 105 patients with peripheral zone lesions of prostate treated in our hospital from January 2019 to November 2022 were selected,including 59 patients with malignant lesions and 46 patients with benign lesions.The difference of ADC values between benign and malignant lesions was analyzed,and the relationship between ADC values and clinicopathology of malignant lesions was analyzed. Results: The ADC value of malignant lesions was (0.81±0.13) × 10-3 mm2/s,which was lower than that of benign lesions (P<0.05).The ADC value of middle and high risk lesions was (0.75±0.16)×10-3 mm2/s,which was lower than low-risk lesions (P<0.05).The ADC values of the lesions in clinical stage C and D were (0.76± 0.15) ×10-3 mm2/s and (0.72±0.14)×10-3 mm2/s,which was lower than that of stage B lesions (P<0.05).There was no significant difference in ADC values among different age,body mass index,lesion diameter and pathological type groups (P>0.05).The ADC value of malignant lesions was negatively correlated with Gleason score (r=-0.343,P<0.05).The area under the ROC curve of malignant lesions judged by ADC value was 0.912 (95% CI:0.839~0.986),P<0.05,and the cut-off value was 0.99×10-3 mm2/s,the sensitivity and specificity were 86.10% and 92.80%,respectively. Conclusion: The ADC value of DWI sequence has a high diagnostic value in differentiating benign and malignant focal lesions around the prostate,and the ADC value is related to the severity and clinical stage.
王凯, 张倩文, 张鹏. DWI序列ADC值鉴别前列腺良恶性局灶性病变的价值[J]. 河北医学, 2023, 29(7): 1126-1129.
WANG Kai, ZHANG Qianwen, ZHANG Peng. The Value of ADC of DWI Sequence in Differentiating Benign and Malignant Focal Lesions of Prostate. HeBei Med, 2023, 29(7): 1126-1129.
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2023, Vol. 29 
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