Abstract：Objective: To explore the efficacy of Fuzheng Yiai decoction supplemented with laparoscopic radical resection of rectal cancer in the treatment of early rectal cancer. Methods: A total of 103 patients with early rectal cancer who underwent radical resection of rectal cancer in the hospital between February 2018 and September 2021 were selected as the research subjects, and they were divided into the treatment group and the control group according to the simple randomization method. The control group (n=51) were given mosapride citrate tablets and FOLFOX4 chemotherapy after surgery, and the treatment group (n=52) was additionally treated with Fuzheng Yiai decoction on the basis of the control group. The scores of TCM syndromes, intestinal microecology, immune function, serum tumor markers [serum carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), Eotaxin-2, cyclooxygenase-2 (COX-2), carbohydrate antigen 199 (CA199)] and adverse drug reactions were compared between the two groups. Results: After 2 months of treatment, the scores of TCM syndromes in the two groups were significantly decreased (P<0.05), the densities of Escherichia coli and Enterococcus were significantly declined (P<0.05) while the densities of Lactobacillus and Bifidobacterium were significantly increased (P<0.05), the proportions of CD3+, CD4+ and NK cells in both groups were significantly enhanced (P<0.05) while the proportion of CD8+ cells was significantly reduced (P<0.05), and the levels of serum CEA, AFP, CA199, COX-2 and Eotaxin-2 were significantly lowered (P<0.05), and the improvement degrees of the above indicators in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion: Laparoscopic radical resection supplemented with Fuzheng Yiai decoction for the treatment of patients with early rectal cancer has significant clinical efficacy and obvious improvements on intestinal microecology and body' immunity.
肖刚, 江静, 罗璐, 李晶, 杨得振. 扶正抑癌汤辅助腹腔镜直肠癌根治术治疗早期直肠癌的疗效观察[J]. 河北医学, 2023, 29(6): 1051-1056.
XIAO Gang, JIANG Jing, LUO Lu, et al. Efficacy of Fuzheng Yiai Decoction Supplemented with Laparoscopic Radical Resection of Rectal Cancer in the Treatment of Early Rectal Cancer. HeBei Med, 2023, 29(6): 1051-1056.
2023, Vol. 29 
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