Abstract：Objective: To investigate the correlation between postpartum haemorrhage and antenatal FIB through systematic review and analysis. Methods: Studies published in the last decade (June 2012-June 2022) on the relationship between postpartum haemorrhage and antenatal FIB levels were collected through a comprehensive search of domestic and international databases. Data were extracted independently by two researchers, and the quality of the extracted literature was evaluated using the evaluation criteria of the NOS literature quality evaluation form. Those with a score ≥6 (high quality) were included in the Meta-analysis, and Meta-analysis was performed using RevMan 5.3 software to evaluate the predictive value of antenatal FIB levels on postpartum haemorrhage. The included literature was analysed by subgroup according to different modes of delivery, degree of bleeding and sample size to evaluate the predictive value of antenatal FIB levels for postpartum haemorrhage; funnel plots were produced using stata software to evaluate the publication bias of the included literature. Results: A total of 10 papers were included in this Meta-analysis. Meta-analysis showed that a reduced antenatal FIB level was predictive of postpartum haemorrhage, mean (MD)=-0.30, 95% confidence interval (95% CI) -0.51 to -0.08, P=0.007; subgroup analysis showed that antenatal FIB level was predictive of postpartum haemorrhage in patients with vaginal delivery. The prenatal FIB level was predictive of the occurrence of severe postpartum haemorrhage. The prenatal FIB level was predictive of the occurrence of postpartum haemorrhage in studies with sample size >1000 and sample size <1000. Conclusion: Prenatal FIB levels can be used as a predictor of postpartum haemorrhage.
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2023, Vol. 29 
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