Abstract：Objective: To investigate the effect of platelet-rich plasma in the treatment of knee osteoarthritis. Methods: 67 Patients with osteoarthritis of the knee were selected from January 2015 to December 2016. The patients were divided into sodium hyaluronate injection control group (34 cases) and platelet-rich plasma injection group (33 cases). The scores of Lysholm knee function scores and VSA pain scores were compared between the two groups before and after treatment. Results: Compared with the control group, the total effective rate of the patients was significantly higher than that of the control group, and the difference was significant (P＜ 0.05). The difference of Lysholm knee function scores between the two groups before treatment was no significant (P ＞0.05). After 1 months of treatment, the Lysholm knee function scores increased significantly, and the difference was significant (P <0.01). After 6 months of treatment, Lysholm knee function scores were down, the control group scores fell as that before injection. While the experimental group, although reduced, but still better than pre-injection score. There was still significant difference between the two groups (P＜0.05). There was no significant difference of the VSA scores between the two groups (P>|0.05). After 1 months of treatment, the VSA scores of the two groups were improved, with the VSA scores of experimental group lower than that of the control group (P＜0.05). But after 6 months of treatment, the VSA scores were significantly decreased in the two groups. The VSA scores of experimental group were still lower than that of the control group, the difference was statistically significant (P <0.05). Conclusion: The use of platelet-rich plasma injection for the treatment of osteoarthritis of the knee is more effective than the sodium hyaluronate injection method, with better knee function recovery and more pain remission, and the effective time is longer. It's worthy for clinical promotion, with reference.
付立功, 陈连旭. 富血小板血浆在膝关节骨关节炎治疗中的应用与临床分析[J]. 河北医学, 2017, 23(9): 1463-1466.
FU Ligong, CHEN Lianxu. The Application and Clinical analysis of Platelet - rich Plasma in the Treatment of Knee Osteoarthritis. 河北医学, 2017, 23(9): 1463-1466.
[1] 吕帅洁,厉驹,何斌,等.富血小板血浆关节内注射治疗膝骨关节炎的前瞻性随机对照研究[J].中华创伤杂志,2016,32(7):626~631. [2] 王加俊,匡志平.富血小板血浆注射治疗膝骨关节炎疗效观察[J].广东医学,2016,37(21):3266~3269. [3] 苏柯,白玉明,王军.关节腔内联合软骨下骨松质骨内注射富血小板血浆治疗膝骨关节炎的疗效观察[J].山东医药,2017,57(13):83~85. [4] Lo Eddie Y,Flanagin Brody A,Burkhead Wayne Z. Biologic resurfacing arthroplasty with acellular human dermal allograft and platelet-rich plasma (PRP) in young patients with glenohumeral arthritis-average of 60 months of at mid-term follow-up[J].Journal of shoulder and elbow surgery,2016,25(7): e199~207. [5] 丁权威,吕帅洁.富血小板血浆联合透明质酸钠关节内注射治疗膝骨关节炎的前瞻性随机对照研究[J].上海医药,2017,38(5):25~28. [6] 邓锦隆,孔繁杰,曾妍.富血小板血浆注射治疗膝关节骨关节炎效果观察[J].现代诊断与治疗,2015,26(8):1814~1815. [7] 刘步云,孙育良,何本祥,等.关节腔注射富血小板血浆与玻璃酸钠治疗膝关节骨关节炎的疗效比较[J].实用骨科杂志,2017,23(1):71~73. [8] Yan Shanshan,Yang Binzhou,Shang Chen,et al.Platelet rich plasma promotes the migration and invasion of synovial fibroblasts in patients with rheumatoid arthritis[J].Molecular medicine reports,2016,14(3): 2269~2275. [9] 徐步靖,霍小燕,张厚庆.关节内注射富血小板血浆与玻璃酸钠治疗膝关节骨关节炎的对比研究[J].中国微创外科杂志,2015,15(8):676~680. [10] 叶卿.耳穴压豆联合富血小板血浆注射治疗膝关节骨性关节炎36例[J].浙江中医杂志,2016,61(2):139. [11] 吴开泽,陈献聪,康禹,等.富血小板血浆在膝关节骨关节炎治疗中的应用[J].国际骨科学杂志,2015,36(6):414~418. [12] A G Hue,H Rkain,H S Abdulmutalib,et al.Place des platelet rich plasma en pathologie traumatique et dégénérative du pied et de la cheville. Revue de la littérature[J].Médecine et Chirurgie du Pied,2016,32(4): 102~108. [13] 张成宝,马信龙,马剑雄,等.富血小板血浆与透明质酸治疗膝骨关节炎疗效的Meta分析[J].实用医学杂志,2015,31(22):3772~3774. [14] 谢磊,刘佳,王华军,等.关节腔注射富血小板血浆对膝关节骨性关节炎的治疗效果[J].中国老年学杂志,2017,37(4):959~960. [15] 冯晓林,牟奎.富血小板血浆用于膝关节骨关节炎的临床研究[J].中华实验外科杂志,2016,33(12):2792~2793.
2017, Vol. 23 
冀公网安备13080202000786号