富血小板纤维蛋白与Bio-Oss骨粉在上颌窦底外提升术中应用价值对比研究

doi:10.3969/j.issn.1006-6233.2023.06.021

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1260 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 探讨富血小板纤维蛋白(PRF)与Bio-Oss骨粉应用于颌窦底外提升术中的临床价值对比研究。方法: 选取2020年7月至2022年1月就诊于我院并接受上颌窦底外提升术疗法的患者120例,随机数字表法简单随机分为PRF组58例,Bio-Oss组62例,PRF组采用富血小板纤维蛋白(PRF)植入干预手术方式,Bio-Oss组采用Bio-Oss骨粉植入干预手术方式,观察两组患者疼痛情况、手术部位黏膜情况、术后骨缺损再生情况及周围软组织健康状况、骨密度变化情况,两组患者治疗前后血小板衍生生长因子(PDGF)、血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)指标水平,Pearman分析骨密度与PDGF、VEGF、TGF-β的相关性。结果: PRF组疼痛表现较Bio-Oss组明显降低,PRF组中黏膜颜色正常的患者比例较Bio-Oss组明显更高,黏膜肿胀程度较Bio-Oss组显著降低;PRF组患者出血指数、探诊深度、附着丧失指标水平较Bio-Oss组明显降低,PRF组植骨高度、成骨厚度指标较Bio-Oss组明显升高(均P<0.05);术后1个月两组患者骨密度较术前水平均明显下降,但PRF组骨密度水平比Bio-Oss组更高(P<0.05);Bio-Oss组术后3个月骨密度值较术后1个月明显升高,但明显低于术前水平,且明显低于PRF组(均P<0.05);,PRF组中各指标水平较Bio-Oss组显著升高(均P<0.05);Pearson相关性分析骨密度与生长因子PDGF、VEGF、TGF-β指标水平,均呈正相关(P<0.05)。结论: 针对患者行上颌窦底外提升术时植入PRF可以促进上颌窦内早期新骨形成,能取得良好的临床效果。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	丁明会
	孔令兵
	杨京宇
	丁明智

关键词 ：富血小板纤维蛋白, Bio-Oss骨粉, 上颌窦底外提升术, 骨密度, 生长因子

Abstract：Objective: To investigate the clinical value of platelet-rich fibrin (PRF) and Bio-Oss bone meal in the clinical value of extra-maxillary sinus lift surgery. Methods: A total of 120 patients who were treated in our hospital from July 2020 to January 2021 and received extra-maxillary sinus lift surgery were selected and simply randomly divided into 58 patients in PRF group and 62 patients in Bio-Oss group by random number table method, with platelet-rich fibrin (PRF) implantation intervention procedure in PRF group and Bio-Oss bone powder implantation intervention procedure in Bio-Oss group. Pain, mucosa at the surgical site, postoperative bone defect regeneration and surrounding soft tissue health were observed in the two groups, bone density changes, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-β(TGF-β) index levels before and after treatment in both groups, Pearman analysis of bone density and PDGF, VEGF, TGF-β correlation was conducted. Results: Pain performance was significantly lower in the PRF group compared with the Bio-Oss group, the proportion of patients with normal mucosal color was significantly higher in the PRF group compared with the Bio-Oss group, and the degree of mucosal swelling was significantly lower compared with the Bio-Oss group; the levels of bleeding index, probing depth, and attachment loss index were significantly lower in the PRF group compared with the Bio-Oss group, and the bone graft height and osteogenic thickness index were significantly higher in the PRF group compared with the Bio-Oss group. Oss group (all P<0.05); BMD in both groups decreased significantly compared to the preoperative level 1 month after surgery, but the PRF group had a higher BMD level than the Bio-Oss group (P<0.05); BMD values in the Bio-Oss group increased significantly at 3 months after surgery compared to 1 month after surgery, but were significantly lower than the preoperative level and significantly lower than the PRF group (all P<0.05); . The levels of each index in the PRF group were significantly higher than those in the Bio-Oss group (all P<0.05); Pearson correlation analysis of BMD and the levels of growth factors PDGF, VEGF and TGF-β indexes showed positive correlation (all P<0.05). Conclusion: PRF implantation in patients undergoing extra-maxillary sinus lift surgery can promote the early formation of new bone in the extra-maxillary sinus and achieve good clinical results.

Key words： PRF Bio-Oss bone powder Extra-maxillary sinus elevation Bone mineral density Growth factor

基金资助:河北省承德市科学技术研究与发展计划项目,(编号:201904A007)

引用本文:

丁明会, 孔令兵, 杨京宇, 丁明智. 富血小板纤维蛋白与Bio-Oss骨粉在上颌窦底外提升术中应用价值对比研究[J]. 河北医学, 2023, 29(6): 990-994.
DING Minghui, KONG Lingbing, YANG Jinyu, et al. A Comparative Study on the Application Value of PRF and Bio-Oss Bone Powder in Extra-Maxillary Sinus Lift Surgery. HeBei Med, 2023, 29(6): 990-994.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.06.021 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I6/990

[1] Zhou W,Wang F,Magic M,et al.The effect of anatomy on osteogenesis after maxillary sinus floor augmentation:a radiographic and histological analysis[J].Clin Oral Investig,2021,25(9):5197-5204.
[2] Parisi L,Buser D,Chappuis V,et al.Cellular responses to deprot-einized bovine bone mineral biofunctionalized with bone-condi-tioned medium[J].Clin Oral Investig,2021,25(4):2159-2173.
[3] 李勇,程如玉,彭学生,等.富自体浓缩生长因子联合Bio-Oss骨粉在颌骨囊肿中的疗效研究[J].中华全科医学,2018,6(7):75-77.
[4] Mudalal M,Sun XL,Li X,et al.Minimally invasive endoscopic maxillary sinus lifting and immediate implant placement:a case report[J].World Clin Cases,2019,7(10):1234-1241.
[5] 马国武,贾崇智.自体牙骨移植材料在口腔种植领域中的应用[J].口腔医学研究,2020,36(8):709-712.
[6] Alalawy,Haider.Bone formation after gelfoam crestal sinus lifting and proposal of a drillless technique[J].Clinical Oral Implants Research,2019,30(19):512.
[7] 衣红梅,薛洪权,吴鸿,等.富含血小板纤维蛋白修复即刻种植体周围骨缺损的临床观察[J].现代口腔医学杂志,2018,1(32):26-28.
[8] 黄稍稍,谭荣才,邝晓岚.Bio-Oss骨粉联合富血小板纤维蛋白在牙槽骨缺损种植引导骨再生后的骨量变化[J].上海口腔医学,2020,29(4):427-430.
[9] 余海云,张国荣,郭静.富血小板纤维蛋白(PRF)对即刻负重种植体周围骨缺损的影响[J].中国实验诊断学,2019,23(8):120-123.
[10] Yalim M,Hendek MK,Ozkan SY,et al.Comparison of the clinical,radiographic,and histological effects of titanium-prepared platelet rich fibrin to allograft materials in sinus-lifting procedures[J].Journal of investigative and clinical dentistry,2018,9(4):1-7.
[11] 黄仙波,董世涛,丁明会,等.3种不同材料在凹面型上颌窦底外提升术中的效果对比[J].河北医学,2021,27(4):650-654.