Abstract：Objective: To study the clinical efficacy of phentolamine pump maintenance in the treatment of neonatal necrotizing enterocolitis (NEC). Methods: A total of 96 children with NEC admitted to Kunming Children's Hospital of Yunnan Province from January 2019 to January 2022 were enrolled in this retrospective analysis. According to different treatment methods, they were divided into study group (48 cases) and control group (48 cases). The control group received conventional treatment, and the study group received phentolamine pump maintenance treatment based on conventional therapy. Comparison was made of serum inflammatory factors [tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-10 (IL-10)], immune indexes [complement 3 (C3), complement 4 (C4), immunoglobulin M (IgM), immunoglobulin A (IgA)] levels and time to resume enteral nutrition, improvement time of stool, disappearance time of abdominal distension, and total effective rate before and after treatment in the two groups. Results: Before treatment, there were no significant differences in the levels of TNF-α, CRP, IL-10, C3, C4, IgM and IgA between the two groups (P>0.05). After treatment, the levels of TNF-α, CRP and IL-10 in the two groups were decreased compared with those before treatment, while the levels of C3, C4, IgM and IgA were increased compared with those before treatment, and the differences were statistically significant (P<0.05). The differences of TNF-α, CRP,IL-10 , C3, C4, IgM and IgA before and after treatment were statistically significant between the two groups (P<0.05). The recovery time of intestinal nutrition, improvement time of stool and disappearance time of abdominal distension were shorter in the study group, and the total effective rate was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusion: Phentolamine pump is effective in the maintenance treatment of NEC, which can reduce the inflammatory response and improve the gastrointestinal and immune function.
忽朋林, 常开朝, 邓声敏, 刘红林. 酚妥拉明泵维持治疗新生儿坏死性小肠结肠炎的临床有效性[J]. 河北医学, 2023, 29(4): 677-681.
HU Penglin, CHANG Kaichao, DENG Shengmin, et al. Clinical Efficacy of Phentolamine Pump Maintenance in the Treatment of Neonatal Necrotizing Enterocolitis. HeBei Med, 2023, 29(4): 677-681.
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2023, Vol. 29 
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