Study on the Effects of Different Treatments on Heart Rate Variability Serum KLK1 and TIMP-1 Levels and Short-Term Prognosis in Patients with Coronary Artery Disease
XIE Xiaoli, et al
986 Hospital of PLA Air Force, Shaanxi Xi'an 710000, China
Abstract：Objective: To investigate the effects of domestic rapamycin drug-eluting stent and paclitaxel drug-eluting balloon on heart rate variability, levels of serum Kallikrein 1 (KLK1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and short-term prognosis in patients with coronary heart disease. Methods: The data of 105 patients with coronary artery disease who received percutaneous coronary intervention in the hospital from November 2019 to May 2021 were reviewed, and they were divided into the observation group (56 cases, using domestic rapamycin drug-eluting stent) and the control group (49 cases, treated with domestic paclitaxel drug-eluting balloon) according to different stents used. The heart rate variability-related indicators [standard deviation of normal sinus RR interval within 5 min (SDNN), standard deviation of the 5-minute average RR intervals (SDANN), percent of differences between adjacent NN intervals greater than 50 ms (pNN50)] before surgery, at 1 week after surgery and at 1 year follow-up, levels of KLK1, TIMP-1, endothelin-1 (ET-1) and nitric oxide (NO) before surgery and at 1 week after surgery as well as short-term prognosis [vascular re-stenosis, vascular re-thrombosis, major adverse cardiovascular events (MACE)] at 1 year of follow-up were compared between the two groups. Results: There were statistical differences in the SDNN, SDANN and pNN50 in repeated measures analysis of variance between the two groups form the aspect of time-point effect (P<0.017), and the above three indicators showed upward trends with the prolongation of postoperative time. The absolute values of differences of serum KLK1, TIMP-1, NO and plasma ET-1 before and after surgery revealed statistically significant differences between the two groups (P<0.05), and the changes in the observation group were greater than those in the control group. At 1 year of follow-up, the incidence rate of vascular re-stenosis in the observation group was lower than that in the control group (P<0.05), but there were no statistically significant differences in the incidence rates of vascular re-thrombosis and MACE between the two groups (P>0.05). Conclusion: Domestic rapamycin drug-eluting stent can effectively regulate heart rate variability in patients with coronary artery disease, and it has a positive effect on improving serum KLK1 and TIMP-1 levels, and can help protect and repair the endothelial function, reduce the risk of stent stenosis, and achieve the good short-term prognosis.
谢晓莉, 王山斌, 王玉静, 弥娜, 谢学建. 不同治疗方法对冠心病患者心率变异性血清KLK1 TIMP-1水平及近期预后的影响研究[J]. 河北医学, 2023, 29(4): 652-657.
XIE Xiaoli, et al. Study on the Effects of Different Treatments on Heart Rate Variability Serum KLK1 and TIMP-1 Levels and Short-Term Prognosis in Patients with Coronary Artery Disease. HeBei Med, 2023, 29(4): 652-657.
2023, Vol. 29 
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