Abstract：Objective: To investigate the distribution of pathogenic bacteria, drug resistance and influencing factors of postoperative pseudojoint infection in patients with knee osteoarthritis in Shijiazhuang Third Hospital from 2016 to 2020. Methods: Totally 1509 patients with knee osteoarthritis who underwent knee surgery in Shijiazhuang Third Hospital from January 2016 to January 2020 were selected and divided into infection group (38 cases) and non-infection group (1471 cases) according to postoperative infection. The knee joint effusion of the infected patients was collected and cultured to detect the types of pathogenic bacteria and drug resistance. Clinical data were collected and multivariate Logistic regression was used to analyze the factors influencing postoperative infection in patients with knee osteoarthritis. Results: A total of 46 strains of pathogenic bacteria were detected, of which 86.96% were Gram-positive bacteria, Gram-positive bacteria were resistant to β-lactam, quinolones and other antibiotics.Duration of operation ≥3h, type 2 diabetes, rheumatoid arthritis, smoking, postoperative urinary tract infection and prevention without antibiotics were risk factors for postoperative periprosthetic infection in patients with knee osteoarthritis (P<0.05). Conclusion: Gram-positive bacteria are the main pathogenic bacteria of pseudojoint infection after knee osteoarthritis, and have high drug resistance rate. Long operation time, type 2 diabetes mellitus, rheumatoid arthritis, smoking, postoperative urinary tract infection and failure to use antibiotics to prevent infection are the main factors leading to infection around pseudarthrosis. Infection monitoring of high-risk patients should be strengthened and antibiotics should be rationally used to reduce the risk of infection.
柴靖, 王豆豆, 王蛟, 王白白. 膝关节骨性关节炎患者术后感染病原菌分布耐药性以及影响因素分析[J]. 河北医学, 2023, 29(4): 617-622.
CHAI Jing, WANG Doudou, WANG Jiao, et al. Distribution of Pathogenic Bacteria, Drug Resistance and Factors Influencing Postoperative Infection in Patients with Osteoarthritis of the Knee Joint. HeBei Med, 2023, 29(4): 617-622.
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2023, Vol. 29 
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