Abstract：Objective: To explore the effectiveness of the combination of two eye drops (domestic sodium hyaluronate plus polyethylene glycol) on xerophthalmia after strabismus surgery. Methods: 89 patients with xerophthalmia after strabismus surgery (89 affected eyes) in the hospital were recruited between January 2021 and February 2022, and they were randomly assigned to regular group (receiving domestic sodium hyaluronate eye drops, n=44, 44 eyes) and combined group (given eye drops of domestic sodium hyaluronate combined with polyethylene glycol, n=45, 45 eyes). The xerophthalmia symptom score, tear film function parameters, clinical efficacy and changes in interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were compared before and after 1 month of treatment. Dry Eye-related Quality-of-life Score (DEQS) was used for the evaluation of quality of life. Results: After treatment, symptom scores and corneal fluorescence staining (Fluorescein, FL) were significantly lower in both groups, while basal tear secretion test (Schirmer I test, SIt) and tear breakup time (BUT) were elevated, and the difference between symptom scores, FL, SIt and BUT before and after treatment in the combined group were ( (4.52±0.35), (2.60±0.93), (6.02±1.55) mm, (5.64±1.73) s, respectively, which were higher than those of the regular group (2.20±0.35), (2.02±1.03), (4.81±1.36) mm, (3.82±1.60) s (P<0.05); 95.56% of the total clinical efficiency and efficacy of the combined group were higher than those of the regular group. The total clinical efficiency and efficacy of 95.56% in the combined group was significantly better than that of 81.82% in the regular group (P<0.05); the levels of IL-8, IL-1β and TNF-α decreased in both groups after treatment, and the differences of IL-8, IL-1β and TNF-α levels in the combined group before and after treatment were (3.06±0.60) ng/L, (20.60±7.66) ng/L and (2.29±0.86) μg/L, respectively. (7.66) ng/L, (2.29±0.86) μg/L, respectively, which were higher than (2.11±0.65) ng/L, (11.06±8.31) ng/L, (1.38±0.93) μg/L in the regular group (all P<0.05); the DEQS scores in the combined group after 2 weeks and 1 month of treatment were (40.17±1.71), ( 32.44±1.16) points, both lower than (44.38±1.89) and (37.56±1.45) points in the regular group (both P<0.05), and the DEQS scores in both groups showed a downward trend after treatment, but the downward trend in the combined group was more obvious than that in the regular group (P<0.05). Conclusion: Domestic sodium hyaluronate combined with polyethylene glycol eye drops can improve xerophthalmia symptom and tear film function after strabismus surgery, with significant efficacy, and can relieve postoperative inflammatory response and improve quality of life.
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2023, Vol. 29 
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