Abstract：Objective: To explore the relationship between different types of dyslipidemia and bone mineral density in physical examination population in Changsha. Methods: A retrospective analysis was performed on the related data of 527 objects undergoing physical examination in the hospital between May 2019 and May 2022. The basic data (blood lipid, bone mineral density) were collected. The objects with normal blood lipid, high triacylglycerol (TG), high cholesterol (TC) and mixed hyperlipidemia were included in normal group (n=140), high TG group (n=70), high TC group (n=159) and mixed group (n=158). The levels of blood lipid and bone mineral density among the four groups were compared. The correlation between blood lipid and bone mineral density, and the effects of blood lipid on bone mineral density were analyzed. Results: LDL-C level was the highest in high TC group, and low in normal group and high TG group. Except for normal group and high TG group, differences in LDL-C level among the other groups were statistically significant (P<0.05). TC in high TC group and mixed group was significantly higher than that in normal group and high TG group (P<0.05). HDL-C level was the highest in high TG group, and the lowest in mixed group (P<0.05). TG level was the highest in mixed group, and the lowest in normal group and high TC group. Except for normal group and high TC group, differences in TG level among the other groups were statistically significant (P<0.05). The ultrasonic velocity of right calcaneus in high TC group and mixed group were significantly lower than those in normal group and high TG group (P<0.05). The ultrasonic velocity of right calcaneus was negatively correlated with LDL-C, TC, HDL-C and TG (P<0.05). Multivariate linear regression analysis showed that influencing factors of bone mineral density were LDL-C, TC, TG and HDL-C. Conclusion: In physical examination population in Changsha, bone mineral density is lower in those with dyslipidemia. Especially, patients with TC and mixed dyslipidemia need regular screening of bone mineral density in order to detect bone mass changes early and conduct targeted preventive treatment.
朱叶牡, 李成, 覃娇, 张利娟, 罗娟, 雷芳, 杨祥友. 长沙地区体检人群不同血脂异常分型与骨密度的关系[J]. 河北医学, 2023, 29(3): 481-486.
ZHU Yemu, LI Cheng, Qin Jiao, et al. Relationship between Different Types of Dyslipidemia and Bone Mineral Density in Physical Examination Population in Changsha. HeBei Med, 2023, 29(3): 481-486.
[1] 曹宗锐,屈晓龙,屈波,等.老年男性2型糖尿病患者骨密度及骨质疏松率的比较分析[J].成都医学院学报,2019,14(1):52-55. [2] 杨弦弦,唐文革,汤成,等.重庆市40岁及以上居民骨质疏松症流行现状及影响因素分析[J].中国慢性病预防与控制,2021,29(10):741-745. [3] Liu K,Wang K,Wang L,et al.Changes of lipid and bone metabolism in broilers with spontaneous femoral head necrosis[J].Poult Sci,2021,100(3):100808-100817. [4] Zhang Y,Wu H,He R,et al.Dickkopf-2 knockdown protects against classic macrophage polarization and lipid loading by activation of Wnt/β-catenin signaling[J].Cardiol,2021,78(4):328-333. [5] 中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016年修订版)[J].中华心血管病杂志,2016,44(10):833-853. [6] Yu L,Xie M,Zhang F,et al.TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes[J].Stem Cell Res Ther,2021,12(1):573. [7] 李野,董书君,宋成超,等.桂西地区骨质疏松患者FRAX评分与体质量指数及外周血中钙、磷指标的相关性分析[J].中国骨质疏松杂志,2021,27(1):123-126. [8] 王谦,董军峰.骨质疏松性椎体骨折椎体成形术后新发骨折的影响因素和注意事项[J].中国组织工程研究,2022,26(27):4401-4405. [9] Karadeniz F,Oh JH,Jo HJ,et al.Dracunculin inhibits adipogenesis in human bone marrow-derived mesenchymal stromal cells by activating AMPK and Wnt/β-catenin signaling[J].Int Mol Sci,2022,23(2):653-667. [10] 云丽媛,吴文侠,李建林.高血糖、高血脂对定量超声骨密度仪诊断桡骨远端骨折患者骨质疏松的影响[J].河北医药,2020,42(10):1554-1556. [11] 修双玲,穆志静,孙丽娜,等.老年2型糖尿病代谢综合征患者骨质疏松危险因素研究[J].首都医科大学学报,2020,41(1):108-112. [12] 周艳,刘晓健,郑玉民,等.北京某高校教职工骨密度与血糖、血脂及血尿酸的相关性[J].中日友好医院学报,2021,35(4):229-231. [13] 王硕,尤凤,查晓娟,等.不同性别健康体检者血生化指标、腹部脂肪分布与骨密度的关系[J].中华骨质疏松和骨矿盐疾病杂志,2020,13(3):210-215.
2023, Vol. 29 
冀公网安备13080202000677号