糖基化间隙与2型糖尿病视网膜病变的相关性研究

doi:10.3969/j.issn.1006-6233.2023.02.023

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1242 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 分析2型糖尿病(T2DM)患者糖基化间隙(GG)与糖尿病视网膜病变(DR)之间的关联性,并探讨GG与DR发生发展的关系。方法: 选择我院2021年9月至2022年4月期间收治的90例T2DM患者,根据是否发生DR将患者分为单纯糖尿病组(T2DM,n=30)和2型糖尿病糖尿病视网膜病变组(T2DR,n=60),根据T2DM患者单因素、多因素分析得出发生DR的危险因素,并绘制ROC曲线,分析GG对T2DM患者发生DR的预测价值。结果: 直线回归分析结果显示,HbA1c与FA之间有直线回归关系(P<0.05)。单因素分析结果显示两组尿素氮(BUN)、血清白蛋白(ALB)、HbA1c、GG差异有统计学意义(P<0.05)。多因素logistic回归分析显示GG是T2DM患者发生DR的危险因素(P<0.05)。ROC结果显示GG预测DR发生发展的AUC为0.777。结论: GG是T2DM患者发生DR的危险因素,有可能成为预测DR发生的标志物。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：糖基化间隙, 糖尿病视网膜病变, 相关性

Abstract：Objective: To analyze the correlation between glycosylation gap (GG) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 90 patients with T2DM were admitted to the hospital from September 2021 to April 2022. They were divided into the T2DM group (n=30) and T2DR group (n=60) according to the presence or absence of DR. Univariate analysis and multivariate analysis were performed to screen the risk factors of DR, and the ROC curve was plotted to analyze the predictive value of GG for DR in patients with T2DM. Results: Linear regression analysis showed that there was a linear regression relationship between HbA1c and FA (P<0.05). Univariate analysis showed that blood urea nitrogen (BUN), serum albumin (ALB), HbA1c, and GG were significantly different in the 2 groups (P<0.05). Multivariate logistic regression analysis showed that GG was a risk factor for DR in patients with T2DM (P<0.05). The ROC analysis results showed that the AUC of GG for predicting DR was 0.777. Conclusion: GG is a risk factor for DR in patients with T2DM, and maybe a marker for predicting the occurrence of DR.

Key words： Glycosylation gap Diabetic retinopathy Correlation

基金资助:安徽省重点研究和开发项目,(编号:1804h08020267)

通讯作者: 时照明

引用本文:

孙杏杏, 徐礼五, 刘晓蓉, 吴翔, 时照明. 糖基化间隙与2型糖尿病视网膜病变的相关性研究[J]. 河北医学, 2023, 29(2): 298-302.
SUN Xingxing, et al. Correlation between Glycosylation Gap and Type 2 Diabetic Retinopathy. HeBei Med, 2023, 29(2): 298-302.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.02.023 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I2/298

[1] Nauck MA,Wefers J,Meier JJ.Treatment of type 2 diabetes:challenges,hopes,and anticipated successes[J].Lancet Diabetes Endocrinol,2021,9(8):525-544.
[2] Bellary S,Kyrou I,Brown JE,et al.Type 2 diabetes mellitus in older adults:clinical considerations and management[J].Nat Rev Endocrinol,2021,17(9):534-548.
[3] Lin KY,Hsih WH,Lin YB,Wen CY,Chang TJ.Update in the epidemiology,risk factors,screening,and treatment of diabetic retinopathy[J].Diabetes Investig,2021,12(8):1322-1325.
[4] 张欣欣,孔悠然,鲍冬青,等.糖化清蛋白与果糖胺反映2型糖尿病血糖变化的比较[J].青岛大学学报(医学版),2021,57(4):551-554.
[5] American Diabetes Association.Standards of medical care in diabetes-2021 abridged for primary care providers[J].Clin Diabetes,2021,39(1):14-43.
[6] American Diabetes Association.6.Glycemic targets:standards of medical care in diabetes-2019[J].Diabetes Care.2019,42(Suppl 1):S61-S70.
[7] 邱海元.空腹血糖、血清果糖胺及糖化血红蛋白联合检测在妊娠期糖尿病诊断中的临床意义[J].中国妇幼保健,2020,35(6):1018-1020.
[8] 段春文,安美霞,刘彦利,等.2型糖尿病患者糖尿病视网膜病变危险评估模型的建立和初步验证[J].中华眼底病杂志,2019,35(2):150-155.
[9] 蒋飞霞,苏宏业,潘海林,等.2型糖尿病患者规范治疗后合并糖尿病视网膜病变及糖尿病肾病的情况及其影响因素[J].广西医学,2018,40(7):775-777,791.
[10] 汤春梦,李文和,杨超超,等.血红蛋白糖化指数与2型糖尿病患者视网膜病变的相关性研究[J].中国糖尿病杂志,2021,29(5):349-352.
[11] 柳杨青,汪艳芳,郭丽君.2型糖尿病患者血清白蛋白水平变化及影响因素分析[J].中华实用诊断与治疗杂志,2019,33(11):1085-1088.
[12] Hsing SC,Lin C,Chen JT,et al.Glycemic gap as a useful surrogate marker for glucose variability and progression of diabetic retinopathy[J].Pers Med,2021,11(8):799-802.
[13] Fishman SL,Sonmez H,Basman C,et al.The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus:a review[J].Mol Med,2018,24(1):59-63.